JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect of the Tongxinluo capsule on primary hypertension

ZHAO Bin1,MAO Yan-yan2,HU Guo-you3,WANG Sheng-hua4   

  1. 1. West Campus Hospital of Shandong University；2. Department of Out-patient, Jinan Government Agency；3. Department of Health Care, General Hospital of Jinan Military Region
  • Received:2006-12-26 Revised:1900-01-01 Online:2007-08-24 Published:2007-08-24
  • Contact: ZHAO Bin

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Abstract: Objective: To observe the depressurization effect of the Tongxinluo capsule on primary hypertension. Methods: Sixty patients with primary hypertension were matched-paired and randomly divided into two groups: 30 in the routine group (RG) treated with captopril, and the other 30 in the Tongxinluo group (TG). At the same time 30 healthy humans were enrolled in the control group (CG). Blood pressure (BP), endothelin (ET) and nitric oxide (NO) were determined both before and after the onemonth treatment. Results: (1) Both Captopril and the Tongxinluo Capsule had a statistically great depressurization effect(P＜0.05); (2) NO was increased and ET was decreased in the TG group(P＜0.05). There was no significant difference among the three groups after treatment(P＞0.05). Conclusion: The Tongxinluo capsule can protect the vascular endothelium by reducing ET and increasing NO and it is an effective medicine for primary hypertension.

Key words: Tongxinluo capsule, Primary hypertension, Endothelin, Nitric oxide

CLC Number: 

  • R544.1
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