JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Association of single nucleotide polymorphism of the C1040T gene encoding TAFI with myocardial infarction

WANG Li-li1，XU Cheng-wei1，YU Chao1，ZHAO Jing-jie2，WU Xiao-ben1，JIANG Cui-ying1，DU Yi-meng3   

  1. 1. Department of Clinical Laboratory; 2. Laboratory of Clinical Molecular Biology； 3. Department of　Cardiology, Second Hospital of Shandong University
  • Received:2007-08-02 Revised:1900-01-01 Online:2007-12-24 Published:2007-12-24
  • Contact: XU Cheng-wei

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Abstract: Objective To explore the association between encoding gene CPB2 polymorphism of thrombin activatable fibrinolysis inhibitor（TAFI）and myocardial infarction. MethodsPCRRFLP (Restriction fragment length polymorphism) method was used to determine the CPB2 gene polymorphism in patients with myocardial infarction（n=100） and healthy controls（n=90）. ResultsThe CPB2 genotyping（Thr/Thr，Thr/Ile and Ile/Ile） frequencies were 32（32%），53（53%）and 15（15%）in the MI group and 31（34.4%），49（54.4%），10（11.2%）in the control group, and the allelic frequencies（C and T）were 117（58.5%）and 83（41.5%） in the MI group and 111（61.7%）and 69（38.3%）in the control group. χ2 analysis showed nonsignificant differences in the Thr325Ile polymorphism distributions（χ2=0.6482，P=0.7232；χ2=0.3958，P=0.5292）；genotype and alleles distribution frequencies were in accordance with the HardyWeinberg equilibrium. ConclusionThe polymorphisms of TAFI gene are not related to myocardial infarction.

Key words: Thrombin activatable fibrinolysis inhibitor, Gene polymorphism, Myocardial infarction(TAFIa)

CLC Number: 

  • R541.4
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