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Anti-oxidative effect of grape seed extract in the human body

FENG Dian-juan，XU Gui-fa   

  1. Institute of Nutrition and Food Hygiene, School of Public, Shandong University
  • Received:2007-04-11 Revised:1900-01-01 Online:2007-10-24 Published:2007-10-24
  • Contact: XU Gui-fa

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Abstract: Objective： To study the anti-oxidative effect of grape seed extract (GSE) in human body. Methods: One hundred healthy volunteers aging from 45 to 65 were randomly divided into two groups: the control group and the GSE-treated group based on the SOD, GSH-Px and MDA levels in serum. The GSE capsule was administered to the GSEtreated group 1g/d orally for 3 months, while no drugs were administered to the control group. The SOD, GSH-Px and MDA levels in serum were determined both prior to and after the experiment. Results: The SOD and GSH-Px levels were significantly higher in the GSE-treated group than in the control group (P＜0.05), while the MDA level was significantly lower in the GSE-treated group than in the control group (P＜0.01). Moreover, there were significant differences in the three indexes in the GSE-treated group between prior to and after the experiment (P＜0.01). Conclusion: GSE has a significantly anti-oxidative effect in vivo.

Key words: Grape seed extract, Proanthocyanidin, Antioxidant

CLC Number: 

  • R151.3
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