JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect of monastrol on mitosis in human pulmonaryadenocarcinoma cell line A549

ZHAO Jian1,CHEN Wei-wen2,WANG Shu-cheng1,LI Xi-bo1,   

  1. 1.Department of Thoracic Surgery, Qilu Hospital of Shandong University; 2. Institute of Biochemistry andMolecular Biology, School of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Received:2005-10-29 Revised:1900-01-01 Online:2006-07-24 Published:2006-07-24

Abstract: To explore the influence of monastrol on mitosis in human pulmonary adenocarcinoma cell line A549. Method: Immunofluorescence stainning and fluorescenceactivated cell sorting techniques were used to detect the the count of cells and the cell cycle. Result: A549 cell was blocked in prometaphase by monastrol and the mitosis cells were monopolar spindlelike. Conclusion: Monastrol can influence mitosis of lung cancer cells, and therefore inhibits the growth of lung cancer cells.

Key words: Lung neoplasms, Monastrol, Mitosis

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