Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (12): 118-124.doi: 10.6040/j.issn.1671-7554.0.2025.0340

• Review • Previous Articles    

Research progress on the mechanism and intervention strategies of cyclic stretch in the intimal hyperplasia after vein graft in coronary artery bypass grafting

QI Zaiwen1, BAI Xiao2, QIN Yuan3   

  1. 1. The Fifth Peoples Hospital of Jinan, Jinan 250022, Shandong, China;
    2. Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. The First School of Clinical Medicine, Shandong University, Jinan 250012, Shandong, China
  • Published:2025-12-19

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Abstract: Intimal hyperplasia of vein graft is a common complication after coronary artery bypass grafting, but the mechanism and prevention strategies of intimal hyperplasia are not fully understood. The cyclic stretch, as a mechanical force stimulation on the vascular wall, was significantly increased after vein graft. The elevated cyclic stretch could affect the content of various gene expression products through epigenetic mechanisms, while regulating various biological functions of cells, ultimately leading to the occurrence of intimal hyperplasia. This article elaborated on the mechanism and intervention measures of cyclic stretch in intimal hyperplasia after vein graft to provide a new perspective for the prevention and treatment of intimal hyperplasia.

Key words: Cyclic stretch, Coronary artery bypass graft, Vein graft, Intimal hyperplasia, Epigenetics

CLC Number: 

  • R654
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