Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (1): 17-24.doi: 10.6040/j.issn.1671-7554.0.2025.0035

• Review • Previous Articles    

Progress in the study of trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients

CHENG Yueqi, WANG Fei, YU Lixiang, ZHENG Chao, YU Zhigang   

  1. Breast Disease Diagnosis and Treatment Center, The Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Published:2025-02-20

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Abstract: Trastuzumab is a humanised monoclonal antibody that targets the human epidermal growth factor receptor 2(HER2)and has shown significant efficacy in the clinical treatment of HER2-positive breast cancer. However, its clinical use may lead to cardiotoxicity issues such as reduction in left ventricular ejection fraction(LVEF), congestive heart failure(CHF)and arrhythmias. The aim of this article is to review current research on trastuzumab-induced cardiotoxicity in the treatment of HER2-positive breast cancer and strategies for monitoring and preventing cardiotoxicity. The aim is to provide a basis for selecting future directions in basic research and optimising clinical management strategies for the use of trastuzumab.

Key words: Breast cancer, Human epidermal growth factor receptor 2, Trastuzumab, Cardiotoxicity, Risk factors

CLC Number: 

  • R541
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