Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (1): 65-70.doi: 10.6040/j.issn.1671-7554.0.2021.0508

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Therapeutic effects of auricular points sticking with magnetic beads combined with repeated transcranial magnetic stimulation on post-stroke depression

ZHAO Xuan1, LI Xiaopeng2, LI Jian1, TIAN Bin1, WANG Guangjun1   

  1. 1. Department of Neurology, Dongying Shengli Hospital, Dongying 257000, Shandong, China;
    2. Department of Physiotherapy, Shengli Oilfield Central Hospital, Dongying 257000, Shandong, China
  • Published:2022-01-08

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Abstract: Objective To investigate the effects of auricular points sticking with magnetic beads combined with repeated transcranial magnetic stimulation(rTMS)on post-stroke depression patients and the effects on the levels of serum transient receptor potential channel 1 protein(TRPC1), serotonin(5-HT), and S100β protein. Methods A total of 120 patients with post-stroke depression were selected and randomly divided into the control group(antidepressant treatment), rTMS group(antidepressant + rTMS), auricular points group(antidepressant + auricular points sticking with magnetic beads treatment), and rTMS + auricular points group(antidepressants + rTMS + auricular points sticking with magnetic beads treatment), with 30 cases in each group and treatment course of 4 weeks. The Hamilton Depression Scale(HAMD)score, clinical efficacy, changes of TRPC1, 5-HT and S100β, and adverse reactions in the four groups were compared. Results Before treatment, there was no significant difference in the HAMD score among the four groups(P>0.05). After treatment, the HAMD score was lower in the rTMS + auricular point group than in other three groups(P<0.05), and the HAMD score in the rTMS and auricular points groups was lower than that in the control group(P<0.05). Before treatment, there were no significant differences in the levels of TRPC1, 5-HT and S100β among the four groups(P>0.05). After treatment, the level of S100β in the rTMS + auricular points group was lower than that in other three groups(P<0.05). The levels of TRPC1 and 5-HT in the rTMS + auricular points group were higher than those in the other three groups(P<0.05). The level of S100β in the rTMS and auricular points groups was lower than that in the control group(P<0.05), and the levels of TRPC1 and 5-HT were higher than in the control group(P<0.05). The total effective rate of the rTMS + auricular points group was higher than that of the other three groups(P<0.05). The total effective rate of the rTMS and auricular points groups was higher than that of the control group(P<0.05). Conclusion Auricular points sticking with magnetic beads combined with rTMS has positive effects in the treatment of post-stroke depression patients, which can effectively adjust the levels of serum TRPC1, 5-HT and S100β, and significantly improve the depression symptoms.

Key words: Repetitive transcranial magnetic stimulation, Auricular point sticking with magnetic beads, Post-stroke depression, Transient receptor potential channel 1 protein, Serotonin, S100β protein

CLC Number: 

  • R743.3
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