Abstract: Objective To investigate the clinical symptoms, diagnosis and treatment of uterine adenosarcoma(UA). Methods The clinical data of 15 UA patients treated during Oct. 2009 and Oct. 2017 were retrospectively analyzed and related literatures were reviewed. Results Irregular vaginal bleeding was observed in 80% of cases. The other symptoms included lower abdominal pain, cervical spondylolysis and so on. The adenosarcoma was located on the cervix in 5 cases and 2 of them had sarcoma overgrowth. According to the FIGO stage(2009), of the 5 cervical adenosarcoma cases, 4 were ⅠB1, and 1 was ⅣB. Of the 10 uterine body adenosarcoma, 2 were ⅠA, 4 were ⅠB, and other 4 were ⅠC, ⅡA, ⅢB and ⅢC respectively. All 15 cases underwent surgical treatment, and 13 of them were treated with chemotherapy. During the follow-up, 4 patients died of disease progression, 1 died of pulmonary embolism after chemotherapy, and 10 survived progression-free. Conclusion UA is a rare disease. As the symptoms and signs are nonspecific, it can easily be misdiagnosed. Therefore, it needs to be differentiated from other benign and malignant lesions, and confirmed by postoperative pathological and immunohistochemical examinations. The disease generally occurs in postmenopausal women, but can also be found in young women. Although it is not malignant, the risk of postoperative recurrence should be evaluated carefully, especially in patients with sarcoma overgrowth, deep myometrial invasion and heterogenous differentiation.

Key words: Uterine adenosarcoma, Diagnosis, Treatment, Prognosis