Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (2): 41-46.doi: 10.6040/j.issn.1671-7554.0.2017.827

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Validity of SPECT/CT bone fusing imaging in the diagnosis of single bone metastasis of lung cancer

WANG Shanrong, DING Yueyun, ZHU Zongping, SHI Dedao, LIU Wanxia, ZHENG Feibo   

  1. Department of Nuclear Medicine, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao 266071, Shandong, China
  • Published:2022-09-28

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Abstract: Objective To investigate the validity of single-photon emission computed tomography/computed tomography(SPECT/CT)bone fusing imaging in the diagnosis of single bone metastasis of lung cancer. Methods A retrospective study was conducted during June 2014 and June 2015 on 80 patients with confirmed lung cancer. All patients underwent 99Tc-methylene diphosphonate whole-body planar bone scintigraphy and had suspected bone metastasis. These patients were then further evaluated with SPECT/CT. The diagnostic results of the two methods were compared. The final results were confirmed with pathology findings(n=3), with more than 2 kinds of radiological imaging findings(n=45), and with 1-year follow-up(n=32). The diagnostic sensitivity, specificity, accuracy, positive and negative predictive values of the two methods were compared. The results were analyzed with SPSS 17.0 software and χ2 test. Results For bone scintigraphy and SPECT/CT fusion imaging, the specificity was 58.3% vs 91.7%(χ2=10.67, P<0.05), accuracy was 71.3% vs 90.0% (χ2=9.002, P<0.05), positive predictive value was 70.6% vs 92.9%(χ2=7.318, P<0.05), sensitivity was 81.8% vs 88.6%(χ2=0.81, P>0.05), and the negative predictive value was 72.4% vs 86.8%(χ2=0.81, P>0.05). Conclusion In the diagnosis of single bone metastasis of lung cancer, the SPECT/CT 山 东 大 学 学 报 (医 学 版)56卷2期 -王善容,等.SPECT/CT融合骨显像诊断肺癌单发骨转移的价值 \=- bone fusion imaging was superior to whole-body planar bone scintigraphy for its specificity, accuracy and positive predictive value. SPECT/CT fusion bone imaging is of great value in the diagnosis of single bone metastasis of lung cancer.

Key words: Single-photon emission computed tomography/computed tomography, Whole bone scintigraphy, Lung cancer, Bone metastasis, Diagnosis

CLC Number: 

  • R445
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