Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (1): 81-85.doi: 10.6040/j.issn.1671-7554.0.2017.750

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Relationship between adipocyte β3 adrenergic receptor expression level and adiposity in adults

CAO Wenyue1,2, PU Ying1, LIU Zhao3, GUO Feng4, YU Jing5, YIN Xiao1   

  1. 1. Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    2. Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    3. Department of Hepatobiliary Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    4. Department of Urology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    5. Operating Room, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To detect relationship between adipocyte β3AR expression and adiposity in adults, and to explore the potential therapeutic target for obesity. Methods A total of 42 adipose tissues were collected from the patients who accepted abdominal operation and divided into overweight group(25≤BMI<30)and normal weight group(BMI<25). β3AR expressions in mRNA and protein levels were detected by qRT-PCR and Western blotting. Results The β3AR mRNA of mature adipocyte(t=2.594, P=0.013), β3AR protein level of mature adipocyte(t=2.760, P=0.010)and preadipocyte(t=2.442, P=0.023)in overweight group were lower than that in normal weight group. There was negative correlation between β3AR mRNA expression and BMI(r=-0.406, P=0.008). Conclusion The down-regulation of adipocyte β3AR expression in overweight group may play an important role in development of obesity.

Key words: β3 adrenergic receptor, Adipocyte, Overweight, Adult

CLC Number: 

  • R589.2
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