肺脏超声在肺表面活性物质治疗早产儿呼吸窘迫综合征中的评价作用

doi:10.6040/j.issn.1671-7554.0.2017.696

Abstract

Abstract: Objective To evaluate the effects of pulmonary surfactant(PS)replacement therapy by using lung ultrasound in preterm infants with respiratory distress syndrome(RDS). Methods A total of 35 preterm infants diagnosed as RDS by clinical and radiographic signs in the Neonatal Intensive Care Unit(NICU)were enrolled into the study from Oct. 2016 to May 2017. Lung ultrasound was performed before and after surfactant replacement therapy within the first 20 hours to 24 hours by the same experienced ultrasonorgaphy physician. The transthoracic approach was performed with longitudinal scans of anterior, lateral and posterior chest walls. Ultrasound findings of each lung field were recorded and typed using the new system. A conventional chest X ray was performed immediately after lung ultrasound was finished. Results All the 35 patients(100%)showed an improvement of lung ultrasound findings observed in one lung field at least within 20 hours to 24 hours after surfactant administration. Three patients showed an improvement of lung ultrasound findings in one or two lung fields, and 32 patients showed an improvement in three or more than three lung areas. After surfactant administration, 30 patients(86%)showed an improvement of chest X ray,and 5 patients showed no improvement. Conclusion Lung ultrasound may enable an early detection of the effect of pulmonary surfactant replacement therapy in preterm RDS infants with the advantages of high sensitivity, non-ionizing and easy-operating.

Key words: Respiratory distress syndrome, Lung ultrasound, Pulmonary surfactant, Preterm infant

CLC Number:

R445

LI Ya, YUAN Peng, ZHANG Feixue, SHAO Guangrui. Lung ultrasound for evaluating the effect of pulmonary surfactant replacement therapy in preterm infants with respiratory distress syndrome[J].Journal of Shandong University (Health Sciences), 2018, 56(2): 34-40.

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Lung ultrasound for evaluating the effect of pulmonary surfactant replacement therapy in preterm infants with respiratory distress syndrome

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