Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (4): 33-37.doi: 10.6040/j.issn.1671-7554.0.2017.1280

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Research advances on the immunological pathogenesis and immunotherapy of premature ovarian failure

QIN Yingying, ZHANG Xiruo   

  1. Department of Reproductive Endocrinology, Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Published:2022-09-27

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Abstract: Premature ovarian failure(POF)is characterized by cessation of ovarian function in women younger than 40 years. It presents highly heterogeneous clinical phenotype and etiology, and greatly jeopardizes the fertility of patients. 山 东 大 学 学 报 (医 学 版)56卷4期 -秦莹莹,等.卵巢早衰的免疫学病因及免疫干预研究进展 \=-Variable causes and pathogeneses have been identified, including chromosome abnormalities, genetic mutations, autoimmune dysfunctions, and iatrogenic, metabolic or infectious factors, whereas a large proportion of causes still remain unknown. Autoimmune dysfunctions are involved in the pathogenesis of 10%-30% of POF cases, evidenced by autoimmune oophoritis complicated with other autoimmune disorders. However, the contribution of autoimmune deregulation to the pathogenesis of ovarian follicles depletion and dysfunction remains elusive. Reliable diagnostic or predictive biomarkers for ovarian autoimmunity are still unavailable at present. The efficacy of immunological interventions needs evidence-based medicine and high quality clinical trials to confirm.

Key words: Premature ovarian failure, Autoimmunity, Autoantibody, Autoimmune oophoritis, Therapy

CLC Number: 

  • R574
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