JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (2): 45-49.doi: 10.6040/j.issn.1671-7554.0.2016.1238

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A dosimetric study of 3D print individual template combination with CT-guided 125I seed implantation for malignant tumors

ZHANG Ying, LIN Qi, YUAN Yuan, DAI Jianjian, GENG Baocheng, XU Ruicai, LIU Yakun, HAN Mingyong   

  1. Department of Health Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2016-09-13 Online:2017-02-10 Published:2017-02-10

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Abstract: Objective To explore the use of 3D print individual template and CT-guided 125I seed implantation in dosimetry by comparing the parameters before and after implantation. Methods A total of 37 patients treated during Feb. and Oct. 2016 were involved. Before implantation, all patients underwent CT scan and the data were saved in digital imaging and communications in medicine(DICOM)format. The individual template was designed by brachytherapy treatment planning system(BTPS), and printed by 3D print technique. Patients received 125I seeds interstitial implantation with the guide of individual template and CT. After implantation, CT scan was performed immediately for dosimetric verification. The pre- and post-operative parameters were compared. Results All 37 individual templates were successfully designed and printed. The range of clinical target volume(CTV)was 5.9-133.1 cc［averaged(36.1±31.3)cc］ vs 5.9-133.6 cc［averaged(37.1±36.6)cc］ in preplan and post implantation, and there was significant difference 山 东 大 学 学 报 (医 学 版)55卷2期 -张颖,等.3D打印个体化模板联合CT引导125I粒子植入治疗肿瘤术前术后剂量学比较 \=-(P<0.001). The prescription dose(PD)was 100-160 Gy. The numbers of preplan seeds and actually implanted seeds were 18-80 vs 24-84. Patients No.2, 6, 12, 14, 15, and 21 received 1-9 complemented seeds during the surgery. The range of D90 was 107.1-187.8 Gy［averaged(144.7±18.8)Gy］ vs 103.9-189.3 Gy［averaged(143.3±20.3)Gy］ in preplan and post implantation, and there was no significant difference(P=0.06). The range of V100 was 83.7%-99.9% ［averaged(96.4±3.1)%］ vs 85.2%-100% ［averaged( 96.9±3.3)%］ in preplan and post implantation, and there was significant difference(P=0.002). Conclusion 3D print individual template and CT-guided 125I seed implantation can ensure the dosimetric quality control in the treatment of malignant tumors, but there are some differences between the preplan and postoperative parameters. Therefore, more clinical experiences still need to be summarized and analyzed.

Key words: Individual template, Iodine-125 seed, Dosimetry, 3D printing

CLC Number: 

  • R730.55
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