JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (12): 33-37.doi: 10.6040/j.issn.1671-7554.0.2015.845

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Preparation of drug/polymer fibers in micrometer or nanometer size and their drug release behavior

CAI Xiaoqing1, ZHAO Qingyun2, GUO Yuanyuan1, LUAN Yuxia1   

  1. 1. College of Pharmacy, Shandong University, Jinan 250012, Shandong, China;
    2. Hospital of Traditional Chinese Medicine of Jimo, Jimo 266200, Shandong, China
  • Received:2015-09-07 Online:2015-12-10 Published:2015-12-10

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Abstract: Objective To prepare the poly(vinyl alcohol) (PVA) fibers loaded with bovine serum albumin (BSA) and to construct a novel drug delivery system. Methods PVA and BSA mixed aqueous solution was quickly frozen using liquid nitrogen then drying for 48 hours, which resulted in the formation of BSA-loaded PVA fibers. The synthesized BSA-loaded PVA fibers were characterized with scanning electron microscopy (SEM), powder X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The drug release behavior of the as-prepared products was also studied. Results The results showed that BSA was successfully incorporated into the biocompatible polymer and the PVA-based fibers had good stability, desired drug loading content and 100% entrapment efficiency. Furthermore, the drug release rate of the as-prepared drug-loaded fibers could be well controlled. The drug release behavior of the BSA-loaded PVA fibers obeyed Biexponential kinetics model with good sustained release. Conclusion The drug release behavior of the micro/nano-fibers demonstrates their promising application in drug delivery system.

Key words: Drug release, Bovine serum albumin, Polymer fiber, Polyvinyl alcohol

CLC Number: 

  • R94
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