HSP70、Caspase3在胶质细胞瘤中的表达及与肿瘤病理分级的关系

山东大学学报(医学版)

HSP70、Caspase3在胶质细胞瘤中的表达及与肿瘤病理分级的关系

郑虹,耿明

山东大学研究生院济南军区总医院干部四科，山东济南 250031

收稿日期:2007-03-16 修回日期:1900-01-01 出版日期:2007-09-24 发布日期:2007-09-24
通讯作者: 耿明

Expression of HSP70 and Caspase3 in human glioma and its relationship with pathological grades

ZHENG Hong， GENG Ming

Graduate School of Shandong University， The Forth Department of Cadre Ward,Military General Hospital of Jinan Command, Jinan 250031, Shandong, China

Received:2007-03-16 Revised:1900-01-01 Online:2007-09-24 Published:2007-09-24
Contact: GENG Ming

摘要/Abstract

摘要： 目的：观察半胱天冬蛋白酶(Caspase3) 和热休克蛋白70(HSP70)在胶质细胞瘤中的表达,探讨Caspase3,HSP70与胶质细胞瘤生物学行为和病理分级的关系。方法: 采用SP免疫组化染色法, 检测50例胶质瘤组织中Caspase3与HSP70蛋白的表达水平,并比较两者的相关性。结果: 随着胶质瘤病理级别的升高, HSP70的表达强度增加，而Caspase3 的表达强度减弱, Ⅰ～Ⅳ级胶质瘤的HSP70阳性率分别为25%、69%、92%、100%(P<0.01),Ⅰ～ Ⅳ级胶质瘤的Caspase3阳性率分别为87.5%、61.5%、38.5%、31%(P<0.05)。Caspase3与HSP70表达存在负相关(P<0.01) 。结论: HSP70与Caspase3蛋白的表达结果提示,两者与胶质瘤的生物学行为和分化程度有关，又对于判断其预后有重要价值。

Abstract: Objective: To explore the correlation between Caspase3 and HSP70 expressions and biologic behaviors and pathological grades of human glioma. Methods: Expressions of Caspase3 and HSP70 and their correlation in human glioma were determined by immunohistochemistry(SP). Results: With the increase of tumor clinical grades，the positive rate of HSP70 was increased and the negative rate of Caspase3 was decreased. Expression rates of HSP70 were 25%, 69%, 92% and 100% in grades of Ⅰ-Ⅳ and expression rates of Caspase3 were 87.5%, 61.5%, 38.5% and 31% in grades of Ⅰ-Ⅳ. There was a negative correlation between Caspase3 and HSP70 expression. Conclusion: Expressions of Caspase3 and HSP 70 are correlated with biological behavior and cell differentiation degrees of glioma. They are important markers for the evaluation of prognosis in glioma.

Key words: Glioma, HSP70, Caspase3, Immunohistochemistry

中图分类号:

R739.34

郑虹,耿明. HSP70、Caspase3在胶质细胞瘤中的表达及与肿瘤病理分级的关系[J]. 山东大学学报(医学版), 2007, 45(9): 944-946.

ZHENG Hong,GENG Ming. Expression of HSP70 and Caspase3 in human glioma and its relationship with pathological grades[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(9): 944-946.

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