饮酒面红预测硝酸甘油缓解心绞痛急性发作的价值

山东大学学报(医学版)

饮酒面红预测硝酸甘油缓解心绞痛急性发作的价值

张鹤^1,2，陈玉国²，徐峰²，薛丽²，张运^1,3

山东大学 1. 教育部和卫生部心血管重构与功能研究重点实验室； 2. 齐鲁医院急诊科； 3. 心血管内科，山东济南 250012

收稿日期:2006-11-28 修回日期:1900-01-01 出版日期:2007-09-24 发布日期:2007-09-24
通讯作者: 陈玉国

Alcohol flushing in predicting the efficacy of nitroglycerin on angina pectoris

ZHANG He^1,2，CHEN Yu-guo²，XU Feng²，XUE Li²，ZHANG Yun^1,3

1. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health; 2. Department of Emergency; 3. Department of Cardiology,Qilu Hospital of Shandong University

Received:2006-11-28 Revised:1900-01-01 Online:2007-09-24 Published:2007-09-24
Contact: CHEN Yu-guo

摘要/Abstract

摘要： 目的：探讨饮酒面红对预测冠心病患者心绞痛急性发作时含服硝酸甘油（GTN）疗效的价值。方法：选择2005年12月至2006年11月经冠状动脉造影确诊为冠心病并符合纳入标准的患者231例，记录冠脉病变并进行Gensini评分。多聚酶链反应检测乙醛脱氢酶2(ALDH2)基因单核苷酸多态性。依据饮酒是否易面红分：不易面红组（n=111）和易面红组（n=120）。调查冠心病危险因素，并测定血常规和血生化指标。观察或询问患者心绞痛发作时GTN疗效，评价两组间GTN疗效差异。结果：两组间性别、年龄、冠心病危险因素、冠脉病变严重程度等均无显著性差异（P＞0.05），饮酒易面红组患者GTN有效率及迅速起效率、ALDH2基因野生型分布均显著低于不易面红组（P＜0.01）。结论：临床工作中可依据患者是否饮酒易面红预测GTN缓解心绞痛急性发作的效果，其机制与ALDH2基因单核苷酸多态性有关。

Abstract: Objective: To investigate the value of alcohol flushing to predict the efficacy of nitroglycerin (GTN) on angina pectoris attacks. Methods: Two hundred and thirty-one patients with coronary heart disease, who were confirmed by coronary angiography, were enrolled in this study and they were divided into two groups according to alcohol flushing: the no-flushing group (n=111) and the flushing group (n=120). The genotype of ALDH2 was determined by polymerase chain reaction and direct sequencing. Risk factors of coronary heart disease and blood routine analysis were determined. The efficacy of nitroglycerin on angina pectoris was gained by a questionnaire. Base clinical characteristics and nitroglycerin efficacy between the two groups were compared. Results: The rate of efficacious response to GTN and the ALDH2*1 genotype in the noflushing group was significantly higher than that in the flushing group (88.3% VS 39.2%, P＜0.01; 85.6% VS 41.7%, P＜0.01). The rate of efficacious response to GTN was significantly higher in patients with the ALDH2*1 genotype than in patients with the ALDH2*2 genotype (80.7% VS 32.6%, P＜0.01). Conclusion: Efficacy of GTN can be predicted by alcohol flushing, which may relate to the effect of gene polymorphisms.

Key words: Coronary heart disease, Flushing, alcohol drinking, Nitroglycerin, Aldehyde dehydrogenase2, Polymorphism, single nucleotide

中图分类号:

R541.4

张鹤,陈玉国,徐峰,薛丽,张运,. 饮酒面红预测硝酸甘油缓解心绞痛急性发作的价值[J]. 山东大学学报(医学版), 2007, 45(9): 927-930.

ZHANG He,CHEN Yu-guo,XU Feng,XUE Li,ZHANG Yun,. Alcohol flushing in predicting the efficacy of nitroglycerin on angina pectoris[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(9): 927-930.

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