山东大学学报 (医学版) ›› 2025, Vol. 63 ›› Issue (9): 65-76.doi: 10.6040/j.issn.1671-7554.0.2025.0310
• 综述 • 上一篇
李雪凯1,孙淋涵1,刘端瑞2,倪阳1
LI Xuekai1, SUN Linhan1, LIU Duanrui2, NI Yang1
摘要： 乳酸化修饰作为一种新型蛋白质翻译后修饰是表观遗传调控的主要机制之一,可以影响蛋白质的结构、功能、活性以及稳定性。乳酸化修饰为更好地理解细胞代谢重编程与表观遗传调控之间的联系提供了新视角。最近越来越多的研究发现乳酸化修饰通过参与炎癌进程、促进炎癌转化和免疫抑制,调控肿瘤的增殖和耐药,并与肿瘤临床不良预后密切相关。阐明乳酸化修饰的分子机制,不仅能为肿瘤治疗提供新的视角和策略,还能推动乳酸研究从基础实验向临床应用的转化。本文综述了乳酸代谢和乳酸化修饰在肿瘤炎癌进程中的作用及机制,突出其在胃肠道、肝脏等多种肿瘤的炎癌进程中发挥的关键作用,这些发现为探索肿瘤发生发展机制及新治疗靶点提供了重要参考。
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