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山东大学学报 (医学版) ›› 2025, Vol. 63 ›› Issue (6): 100-106.doi: 10.6040/j.issn.1671-7554.0.2025.0216

• 临床医学 • 上一篇    

基础生理指标对甲状旁腺功能的影响

刘凯林1*,郭莹1*,王志昊1,耿冲1,王娜娜2   

  1. 1.山东第一医科大学附属省立医院乳腺甲状腺外科, 山东 济南 250021;2.山东省第二人民医院乳腺疾病二科、甲状腺疾病二科, 山东 济南 250022
  • 发布日期:2025-07-08
  • 通讯作者: 耿冲. E-mail:cgeng@email.sdfmu.edu.cn王娜娜. E-mail:18363037353@163.com*共同第一作者
  • 基金资助:
    国家自然科学基金(82470822);山东省自然科学基金(ZR2024MH307)

Influence of physiological indicators on parathyroid gland function

LIU Kailin1*, GUO Ying1*, WANG Zhihao1, GENG Chong1, WANG Nana2   

  1. 1. Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;
    2. Second Department of Breast Diseases, Second Department of Thyroid Diseases, Shandong Second Provincial General Hospital, Jinan 250022, Shandong, China
  • Published:2025-07-08

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摘要： 目的 分析多种基础生理指标对甲状旁腺激素(parathyroid hormone, PTH)水平的影响,探讨其在PTH代谢调控中的作用。 方法 回顾性分析2023年10月至2024年10月期间1 391例符合研究标准的住院患者的临床资料,通过Spearman相关性分析及逐步多元线性回归分析以确定血清PTH水平的主要影响因素。同时,回顾性分析2022年1月至2024年11月期间2 034例患者资料以研究季节因素对PTH的影响,311例患者资料以研究季节因素对25-羟基维生素D水平的影响。 结果 多元线性回归分析显示,BMI(β=0.157, P<0.001)、白蛋白(albumin, ALB)(β=0.095, P=0.001)、游离脂肪酸(free fatty acids, FFA)(β=0.177, P<0.001)与血清PTH水平呈正相关;而视黄醇结合蛋白(retinol-binding protein, RBP)(β=-0.056, P=0.048)、血钙(β=-0.309, P<0.001)与血清PTH水平呈负相关。血清PTH和25-羟基维生素D水平受季节变化影响,PTH水平在3月、8-9月较低,5月达到峰值,25-羟基维生素D在7-10月处于全年较高水平。未发现PTH水平存在性别差异。 结论 血清PTH水平与BMI、ALB、FFA呈正相关,与RBP、血钙呈负相关;性别差异对PTH水平没有影响。PTH与25-羟基维生素D水平总体呈现反向变化趋势,提示代谢相关因素和季节变化在PTH调控中可能具有重要作用。

关键词: 甲状旁腺激素, 体质量指数, 视黄醇结合蛋白, 血糖, 25-羟基维生素D

Abstract: Objective To analyze the influence of various basic physiological indicators on parathyroid hormone(PTH)levels and explore their roles in the regulation of PTH metabolism. Methods A retrospective analysis was conducted on the clinical data of 1,391 hospitalized patients from October 2023 to October 2024. Spearman correlation analysis and stepwise multiple linear regression were employed to identify the major determinants of serum PTH levels. Additionally, data from 2,034 and 311 patients between January 2022 and November 2024 were retrospectively analyzed to investigate the impact of seasonal variation on PTH and 25-hydroxyvitamin D ［25(OH)D］ levels, respectively. Results Multiple linear regression analysis indicated that BMI(β=0.157, P<0.001), albumin(ALB)(β=0.095, P=0.001), and free fatty acids(FFA)(β=0.177, P<0.001)were positively associated with serum PTH levels, whereas retinol-binding protein(RBP)(β=-0.056, P=0.048)and Ca2+(β=-0.309, P<0.001)were negatively associated with PTH levels. Additionally, serum PTH and 25(OH)D levels exhibited seasonal variations, with PTH levels being lower in March and from August to September, peaking in May. Meanwhile, 25(OH)D levels remained higher from July to October. No significant gender differences in PTH levels were observed. Conclusion Serum PTH levels are positively correlated with BMI, ALB, and FFA, and negatively correlated with RBP and Ca2+. In addition, gender differences have no effect on PTH levels. PTH levels exhibit an overall inverse trend with 25(OH)D levels, suggesting that metabolic factors and seasonal variations may play an important role in the regulation of PTH.

Key words: Parathyroid hormone, Body mass index, Retinol-binding protein, Blood glucose, 25-hydroxyvitamin D

中图分类号: 

  • R582
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