136例2型糖尿病患者肌肉痉挛的发生频率及危险因素

doi:10.6040/j.issn.1671-7554.0.2022.1164

摘要/Abstract

摘要： 目的探讨2型糖尿病(T2DM)患者发生肌肉痉挛的频率及危险因素。方法选取2021年7月至9月于山东大学齐鲁医院内分泌科住院的136例T2DM患者为研究对象,根据肌肉痉挛量表评估的结果,分为肌肉痉挛组(n=65)、无肌肉痉挛组(n=71)。收集两组患者年龄、性别、吸烟饮酒史、体质量指数(BMI)、平均动脉压(MAP)、糖尿病病程、血糖、糖化血红蛋白(HbA1c)、空腹C肽,以及血清肌酐(Scr)、白蛋白(ALB)、总钙(Ca)、镁(Mg)、维生素D(VIT-D)水平等一般情况和临床资料。应用多因素二分类Logistic回归分析影响T2DM患者合并肌肉痉挛的危险因素。结果 47.8%(65/136)患者存在不同程度的肌肉痉挛,其血白蛋白水平显著低于无肌肉痉挛患者(P=0.023),糖尿病病程亦明显延长(P=0.045);两组年龄、性别、吸烟率、饮酒率、BMI、MAP及血糖、HbA1c、空腹C肽、Scr、Ca、Mg、VIT-D水平差异无统计学意义(P均>0.05)。多因素Logistic回归分析显示,糖尿病病程长(OR=1.068,95%CI:1.008~1.131)和低血白蛋白水平(OR=1.159,95%CI:1.015~1.323)为T2DM肌肉痉挛的独立危险因素。结论长糖尿病病程和低血白蛋白水平可能是T2DM患者发生肌肉痉挛的独立危险因素。

关键词: 2型糖尿病, 肌肉痉挛, 糖尿病病程, 白蛋白

Abstract: Objective To investigate the frequency of muscle cramp and analyze the risk factors in patients with type 2 diabetes mellitus(T2DM). Methods A total of 136 T2DM patients were involved and assessed with the Muscle Spasm Scale. According to the results of the scale, they were divided into muscle cramp group(n=65)and non muscle cramp group(n=71). Patients age, gender, body mass index(BMI), smoking history, alcohol consumption, mean arterial pressure(MAP), duration of diabetes, plasma glucose, glycosylated hemoglobin A1c(HbA1c), fasting C-peptide, serum albumin(ALB), serum creatinine(Scr), magnesium(Mg), total calcium(Ca)and vitamin D(VIT-D)were assessed. Risk factors of muscle cramp were screened with multivariate binary Logistic regression. Results The study revealed that47.8%(65/136)patients suffered from various degrees of muscle cramp. The ALB level of the muscle cramp group was significantly lower than that of the non muscle spasm group(P=0.023). The duration of diabetes was also significantly prolonged(P=0.045). There were no significant differences in other parameters between the two groups(P>0.05). Multivariate Logistic regression showed that increased duration of diabetes(OR=1.068, 95%CI: 1.008-1.131)and reduced ALB level(OR=1.159, 95%CI: 1.015-1.323)were independent risk factors of muscle cramp. Conclusion Decreased ALB level and extended diabetes duration may be independent risk factors for the occurrence of muscle cramp in patients with T2DM.

Key words: Type 2 diabetes mellitus, Muscle cramp, Duration of diabetes, Albumin

中图分类号:

R587.1

李金泉,高美芳,闫飞,董明. 136例2型糖尿病患者肌肉痉挛的发生频率及危险因素[J]. 山东大学学报 (医学版), 2023, 61(5): 20-24.

LI Jinquan, GAO Meifang, YAN Fei, DONG Ming. Frequency and risk factors of muscle cramp in 136 cases of type 2 diabetes mellitus[J]. Journal of Shandong University (Health Sciences), 2023, 61(5): 20-24.

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