山东大学学报 (医学版) ›› 2020, Vol. 58 ›› Issue (5): 107-114.doi: 10.6040/j.issn.1671-7554.0.2019.721
• • 上一篇
李云霞1,2,李洪凯1,2,马韫韬3,于媛媛1,2,孙晓茹1,2,刘新辉1,2, 司书成1,2,侯蕾1,2,袁同慧1,2,刘璐1,2,李文超1,2,薛付忠1,2,刘言训1,2
LI Yunxia1,2, LI Hongkai1,2, MA Yuntao3, YU Yuanyuan1,2, SUN Xiaoru1,2, LIU Xinhui1,2, SI Shucheng1,2, HOU Lei1,2, YUAN Tonghui1,2, LIU Lu1,2, LI Wenchao1,2, XUE Fuzhong1,2, LIU Yanxun1,2
摘要: 目的 采用孟德尔随机化方法探讨身高和冠心病之间的因果关系。 方法 对基于全基因关联研究(GWAS)的Meta分析数据进行二次数据分析。利用大样本GWAS汇总数据,选择与身高密切相关的遗传位点作为工具变量,分别用逆方差加权法、加权中位数法和MR-Egger回归作两样本孟德尔随机化分析,以OR值评价身高与冠心病之间的因果关系。 结果 共纳入108个SNP位点作为工具变量,随机效应逆方差加权法和加权中位数法估计得OR值分别为0.760 5(0.644 8~0.896 9)和0.737 9(0.589 9~0.923 1),两种方法结果相近,均支持身高与冠心病之间存在因果关系。MR-Egger回归方程截距项为-0.003 1(-0.013 8~0.007 6),表明因果估计结果受基因多效性影响的可能性较小。身高每增加一倍标准差(SD=0.0699m),冠心病风险降低约25%。 结论 身高与冠心病之间存在负向因果关联。
中图分类号:
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