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山东大学学报 (医学版) ›› 2020, Vol. 58 ›› Issue (4): 100-104.doi: 10.6040/j.issn.1671-7554.0.2019.1418

• • 上一篇    

抗苗勒管激素与女性自然妊娠能力的关联分析

高任远1,张敬2,刘方方2,李瑞静2,张秀清3,秦莹莹1   

  1. 1.山东大学附属生殖医院生殖内分泌科, 山东 济南 250021;2.山东大学附属生殖医院健康管理部, 山东 济南 250021;3.山东大学附属省立医院, 山东 济南 250021
  • 发布日期:2022-09-27
  • 通讯作者: 张秀清. E-mail:xiuqing132@163.com
  • 基金资助:
    国家重点研发计划项目(2017YFC1001100),山东省医药卫生科技发展计划(2016Ws0367)

Correlation between anti-müllerian hormone and natural reproductive potential in women

GAO Renyuan1, ZHANG Jing2, LIU Fangfang2, LI Ruijing2, ZHANG Xiuqing3, QIN Yingying1   

  1. 1. Department of Reproductive Endocrinology, Center for Reproductive Medicine, Shandong University, Jinan 250021, Shandong, China;
    2. Department of Health Management, Center for Reproductive Medicine, Shandong University, Jinan 250021, Shandong, China;
    3. Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Published:2022-09-27

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摘要： 目的 探讨血清抗苗勒管激素(AMH)与育龄期女性自然妊娠能力的关联性。 方法 收集2016年1月至2018年5月在山东大学附属生殖医院进行健康查体的601例育龄期女性的临床资料。将受试者按年龄分为低龄组(≤35岁,n=292)和高龄组(>35岁,n=309);每组根据AMH水平,进一步分为低AMH(<1.0 ng/mL)、中AMH(1.0~3.5 ng/mL)以及高AMH(>3.5 ng/mL)3个亚组。随访12个月,比较不同年龄组、不同AMH水平女性的自然受孕率。 结果 601名女性中,202例(33.61%)在12个月随访期内获自然妊娠,其中低龄组临床妊娠率为53.42%(156/292)、高龄组为14.89%(46/309)。低龄组:高、中、低 AMH组的临床妊娠率分别为54.97%(94/171)、56.38%(53/94)、33.33%(9/27),差异无统计学意义(P=0.09);AMH水平与低龄女性自然妊娠率无关联。高龄组:高、中、低AMH组临床妊娠率分别为35.71%(15/42)、21.10%(23/109)、5.06%(8/158),高AMH女性的自然妊娠率较中、低AMH组高,差异有统计学意义(P<0.05);ROC曲线显示,AMH对高龄女性的自然妊娠能力具有一定预测价值(AUCAMH=0.74)。 结论 血清AMH水平对高育龄女性的自然妊娠能力具有一定预测价值,但不能作为年轻女性生育潜能的惟一评价指标。

关键词: 抗苗勒管激素, 年龄, 自然妊娠, 生育力

Abstract: Objective To evaluate the relationship between serum level of anti-müllerian hormone(AMH)and natural reproductive potential in women of childbearing age. Methods Clinical data of 601 women who underwent physical examination during Jan. 2016 and May 2018 were collected. The patients were divided into two groups: young age group(≤35 years old, n=292)and advanced age group(>35 years old, n=309). According to the level of AMH, the two group were further divided into three subgroups: low AMH(<1.0 ng/mL), normal AMH(1.0~3.5 ng/mL)and high AMH(>3.5 ng/mL)groups. All women were followed up for 12 months to observe the natural conception 山 东 大 学 学 报 (医 学 版)58卷4期 -高任远,等.抗苗勒管激素与女性自然妊娠能力的关联分析 \=-rate. Results During the follow-up of 12 months, 202(33.61%)participants were pregnant. The clinical pregnancy rate was 53.42%(156/292)in the young age group and 14.89%(46/309)in the advanced age group. In the young age group, the clinical pregnancy rate in high, normal and low AMH subgroups was 54.97%(94/171), 56.38%(53/94)and 33.33%(9/27), respectively, with no significant difference(P=0.09). In the advanced age group, the clinical pregnancy rate in high, normal and low AMH subgroups was 35.71%(15/42), 21.10%(23/109)and 5.06%(8/158), respectively. A strong correlation was observed between AMH and natural conception rate(P<0.05). The ROC curve showed that AMH had certain predictive value for natural reproductive potential in the advanced age group(AUCAMH=0.74). Conclusion Serum level of AMH is a promising predictor for fertility in advanced age women, but not in young women.

Key words: Anti-müllerian hormone, Age, Natural conception, Fertility

中图分类号: 

  • R711.75
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