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山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (2): 16-22.doi: 10.6040/j.issn.1671-7554.0.2018.1392

• • 上一篇    

卵巢衰老的机制与预防研究进展

王世宣,张金金   

  1. 华中科技大学同济医学院附属同济医院妇产科, 湖北 武汉 430030
  • 发布日期:2022-09-27
  • 通讯作者: 王世宣. E-mail:sxwang@tjh.tjmu.edu.cn
  • 基金资助:
    国家重点研发项目(2016YFC1302900);国家自然科学基金(81671394,81370469,81873824)

Advances in the mechanisms research and preventive measures of ovarian aging

WANG Shixuan, ZHANG Jinjin   

  1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China)〓山〓东〓大〓学〓学〓报〓(医〓学〓版)57卷2期〓-王世宣, 等.卵巢衰老的机制与预防研究进展〓\=-
  • Published:2022-09-27

摘要: 衰老驱动了多种疾病的发生发展,延缓衰老是疾病防治最好的方法。器官衰老的特殊类型——卵巢衰老,是一个具有重要影响的疾病状态,深入研究卵巢衰老的发生发展机制,探讨可能的延缓卵巢衰老思路和策略,对于女性卵巢衰老及老年性疾病的防治、人口老龄化状态的改善及中老年人群健康的维系格外重要。综述卵巢衰老机制研究和预防策略的研究现状,为卵巢衰老的防治以及进一步研究提供理论依据与方向指导。

关键词: 器官衰老, 卵巢衰老, 机制研究, 预防策略

Abstract: As aging causes many diseases, delaying the process of aging can prevent some of the diseases. Ovarian aging,a special type of organ senescence, is considered as the pacemaker of female body aging, which drives the aging of multiple organs and leads to several aging associated disorders. Hence, it is of great significance to investigate the mechanisms of ovarian aging and explore ways to delay the progress. This review attempts to discuss the latest advances in the molecular mechanisms of ovarian aging and the current status of preventive measures, in order to offer new insights into the prevention and treatment of ovarian aging and related diseases.

Key words: Organ senescence, Ovarian aging, Mechanisms research, Preventive measures

中图分类号: 

  • R711
[1] Couzin-Frankel J. Reproductive biology. Faulty DNA repair linked to ovarian aging in mice and humans[J]. Science, 2013, 339(6121): 749. doi:10.1126/science.339.6121.749.
[2] Nelson HD. Menopause[J]. The Lancet, 2008, 371(9614): 760-770.
[3] Research on the menopause in the 1990s. Report of a WHO Scientific Group[J]. World Health Organ Tech Rep Ser, 1996, 866: 1-107.
[4] 中华预防医学会. 更年期妇女保健指南(2015年)[J]. 实用妇科内分泌杂志, 2016, 3(2): 21-32. Chinese Preventive Medicine Association. Guideline of menopause health care(2015)[J]. J Pract Gynecol Endocrinol, 2016, 3(2): 21-32.
[5] Lu JY, Wang ZX, Cao J, et al. A novel and compact review on the role of oxidative stress in female reproduction[J]. Reprod Biol Endocrinol, 2018, 16(1): 80. doi: 10.1186/s12958-018-0391-5.
[6] Wang S, He GL, Chen M, et al. The role of antioxidant enzymes in the ovaries[J]. Oxid Med Cell Longev, 2017, 2017: 4371714. doi:10.1155/2017/4371714.
[7] Zhang D, Keilty D, Zhang ZF, et al. Mitochondria in oocyte aging: current understanding[J]. Facts Views Vis Obgyn, 2017, 9(1): 29-38.
[8] Liu XT, Lin X, Zhang SY, et al. Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway[J]. Aging(Albany NY), 2018, 10(8): 2016-2036.
[9] Weng QN, Liu ZQ, Li BJ, et al. Oxidative stress induces mouse follicular granulosa cells apoptosis via JNK/FoxO1 pathway[J]. PLoS One, 2016, 11(12): e0167869. doi: 10.1371/journal.pone.0167869.
[10] Nelson SM, Telfer EE, Anderson RA. The ageing ovary and uterus: new biological insights[J]. Hum Reprod Update, 2013, 19(1): 67-83.
[11] Ye HF, Li XY, Zheng TC, et al. The effect of the immune system on ovarian function and features of ovarian germline stem cells[J]. Springerplus, 2016, 5(1): 990. doi:10.1186/s40064-016-2390-3.
[12] Laven JS. Genetics of early and normal menopause[J]. Semin Reprod Med, 2015, 33(6): 377-383.
[13] Jiao X, Qin C, Li J, et al. Cytogenetic analysis of 531 Chinese women with premature ovarian failure[J]. Human Reproduction, 2012, 27(7): 2201-2207.
[14] Perry JR, Hsu YH, Chasman DI, et al. DNA mismatch repair gene MSH6 implicated in determining age at natural menopause[J]. Hum Mol Genet, 2014, 23(9): 2490-2497.
[15] Broekmans FJ, Soules MR, Fauser BC. Ovarian aging: mechanisms and clinical consequences[J]. Endocr Rev, 2009, 30(5): 465-493.
[16] AlAsiri S, Basit S, Wood-Trageser MA, et al. Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability[J]. J Clin Invest, 2015, 125(1): 258-262.
[17] Wainer-Katsir K, Zou JY, Linial M. Extended fertility and longevity: the genetic and epigenetic link[J]. Fertil Steril, 2015, 103(5): 1117-1124.
[18] von Meyenn F, Reik W. Forget the parents: epigenetic reprogramming in human germ cells[J]. Cell, 2015, 161(6): 1248-1251.
[19] Li H, Liu J, Sun Y, et al. N-hexane inhalation during pregnancy alters DNA promoter methylation in the ovarian granulosa cells of rat offspring[J]. J Appl Toxicol, 2014, 34(8): 841-856.
[20] 王伟聿, 唐莉. 卵巢功能早衰中端粒及端粒酶作用的研究进展[J]. 基础医学与临床, 2014, 34(7): 1002-1005. WANG Weiyu, TANG Li. The research advances in the role of telomere/telomerase in premature ovarian failure[J]. Basic Medical Sciences and Clinics, 2014, 34(7): 1002-1005.
[21] Ozturk S, Sozen B, Demir N. Telomere length and telomerase activity during oocyte maturation and early embryo development in mammalian species[J]. Mol Hum Reprod, 2014, 20(1): 15-30.
[22] Liu JP, Li H. Telomerase in the ovary[J]. Reproduction, 2010, 140(2): 215-222.
[23] Rocca MS, Foresta C, Ferlin A. Telomere length: lights and shadows on their role in human reproduction[J]. Biol Reprod, 2018. doi: 10.1093/biolre/ioy208.
[24] Xu XF, Chen XX, Zhang XR, et al. Impaired telomere length and telomerase activity in peripheral blood leukocytes and granulosa cells in patients with biochemical primary ovarian insufficiency[J]. Hum Reprod, 2017, 32(1): 201-207.
[25] Ross JM, Coppotelli G, Hoffer BJ, et al. Maternally transmitted mitochondrial DNA mutations can reduce lifespan[J]. Sci Rep, 2014, 4: 6569. doi:10.1038/srep06569.
[26] Ross JM, Stewart JB, Hagström E, et al. Germline mitochondrial DNA mutations aggravate ageing and can impair brain development[J]. Nature, 2013, 501(7467): 412-415.
[27] Wang TR, Zhang M, Jiang ZL, et al. Mitochondrial dysfunction and ovarian aging[J]. Am J Reprod Immunol, 2017, 77(5): 01 doi:10.1111/aji.12651.
[28] Carré J, Gatimel N, Moreau J, et al. Does air pollution play a role in infertility?: a systematic review[J]. Environ Health, 2017, 16(1): 82. doi:10.1186/s12940-017-0291-8.
[29] Mahalingaiah S, Missmer SE, Cheng JJ, et al. Perimenarchal air pollution exposure and menstrual disorders[J]. Hum Reprod, 2018, 33(3): 512-519.
[30] Brucker-Davis F, Thayer K, Colborn T. Significant effects of mild endogenous hormonal changes in humans: considerations for low-dose testing[J]. Environ Health Perspect, 2001, 109(Suppl 1): 21-26.
[31] Richardson MC, Guo M, Fauser BC, et al. Environmental and developmental origins of ovarian reserve[J]. Hum Reprod Update, 2014, 20(3): 353-369.
[32] Matikainen T, Perez GI, Jurisicova A, et al. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals[J]. Nat Genet, 2001, 28(4): 355-360.
[33] Moyer B, Hixon ML. Reproductive effects in F1 adult females exposed in utero to moderate to high doses of mono-2-ethylhexylphthalate(MEHP)[J]. Reprod Toxicol, 2012, 34(1): 43-50.
[34] Hyland A, Piazza K, Hovey KM, et al. Associations between lifetime tobacco exposure with infertility and age at natural menopause: the Womens Health Initiative Observational Study[J]. Tob Control, 2016, 25(6): 706-714.
[35] Fraser A, McNally W, Sattar N, et al. Prenatal exposures and anti-Mullerian hormone in female adolescents: the Avon Longitudinal Study of Parents and Children[J]. Am J Epidemiol, 2013, 178(9): 1414-1423.
[36] Gannon AM, Stämpfli MR, Foster WG. Cigarette smoke exposure leads to follicle loss via an alternative ovarian cell death pathway in a mouse model[J]. Toxicol Sci, 2012, 125(1): 274-284.
[37] Camlin NJ, Sobinoff AP, Sutherland JM, et al. Maternal smoke exposure impairs the long-term fertility of female offspring in a murine model[J]. Biol Reprod, 2016, 94(2): 39. doi:10.1095/biolreprod.115.135848.
[38] Hawkins Bressler L, Bernardi LA, De Chavez PJ, et al. Alcohol, cigarette smoking, and ovarian reserve in reproductive-age African-American women[J]. Am J Obstet Gynecol, 2016, 215(6): 758. doi:10.1016/j.ajog.2016.07.012.
[39] Erbas O, Pala HG, Pala EE, et al. Therapeutic effect of sunitinib on diabetes mellitus related ovarian injury: an experimental rat model study[J]. Gynecol Endocrinol, 2015, 31(5): 388-391.
[40] Cooper GS, Baird DD, Darden FR. Measures of menopausal status in relation to demographic, reproductive, and behavioral characteristics in a population-based study of women aged 35-49 years[J]. Am J Epidemiol, 2001, 153(12): 1159-1165.
[41] Lambertini M, Del Mastro L, Pescio MC, et al. Cancer and fertility preservation: international recommendations from an expert meeting[J]. BMC Med, 2016, 14: 1. doi:10.1186/s12916-015-0545-7.
[42] Codacci-Pisanelli G, Del Pup L, Del Grande M, et al. Mechanisms of chemotherapy-induced ovarian damage in breast cancer patients[J]. Crit Rev Oncol Hematol, 2017, 113: 90-96. doi:10.1016/j.critrevon.2017.03.009.
[43] Morgan S, Anderson RA, Gourley C, et al. How do chemotherapeutic agents damage the ovary?[J]. Hum Reprod Update, 2012, 18(5): 525-535.
[44] Bedoschi G, Navarro PA, Oktay K. Chemotherapy-induced damage to ovary: mechanisms and clinical impact[J]. Future Oncol, 2016, 12(20): 2333-2344.
[45] Baidoo KE, Yong K, Brechbiel MW. Molecular pathways: targeted α-particle radiation therapy[J]. Clin Cancer Res, 2013, 19(3): 530-537.
[46] Gao W, Liang JX, Ma C, et al. The protective effect of N-acetylcysteine on ionizing radiation induced ovarian failure and loss of ovarian reserve in female mouse[J]. Biomed Res Int, 2017, 2017: 4176170. doi:10.1155/2017/4176170.
[47] Ebrahimi M, Akbari Asbagh F. Pathogenesis and causes of premature ovarian failure: an update[J]. Int J Fertil Steril, 2011, 5(2): 54-65.
[48] 张辉, 韩波. 自身抗体与卵巢早衰相关性分析[J]. 慢性病学杂志, 2010, 12(3): 221-222. ZHANG Hui, HAN Bo. Correlation analysis of autoantibodies and pemature ovarian failure[J]. Chronic Pathematology Journal, 2010, 12(3): 221-222.
[49] Dragojevic-Dikic S, Marisavljevic D, Mitrovic A, et al. An immunological insight into premature ovarian failure(POF)[J]. Autoimmun Rev, 2010, 9(11): 771-774. doi:10.1016/j.autrev.2010.06.008.
[50] Lin YH, Chen YH, Chang HY, et al. Chronic niche inflammation in endometriosis-associated infertility: current understanding and future therapeutic strategies[J]. Int J Mol Sci, 2018, 19(8): E2385. doi:10.3390/ijms19082385.
[51] Pal L, Bevilacqua K, Santoro NF. Chronic psychosocial stressors are detrimental to ovarian reserve: a study of infertile women[J]. J Psychosom Obstet Gynaecol, 2010, 31(3): 130-139.
[52] Park JH, Rivière I, Gonen M, et al. Long-term follow-up of CD19 CAR therapy in acute lymphoblastic leukemia[J]. N Engl J Med, 2018, 378(5): 449-459. doi:10.1056/NEJMoa1709919.
[53] Hendrick V, Gitlin M, Altshuler L, et al. Antidepressant medications, mood and male fertility[J]. Psychoneuroendocrinology, 2000, 25(1): 37-51.
[54] Dorjgochoo T, Kallianpur A, Gao YT, et al. Dietary and lifestyle predictors of age at natural menopause and reproductive span in the Shanghai Womens Health Study[J]. Menopause, 2008, 15(5): 924-933.
[55] Sapre S, Thakur R. Lifestyle and dietary factors determine age at natural menopause[J]. J Midlife Health, 2014, 5(1): 3-5.
[56] Hawkins Bressler L, Bernardi LA, De Chavez PJ, et al. Alcohol, cigarette smoking, and ovarian reserve in reproductive-age African-American women[J]. Am J Obstet Gynecol, 2016, 215(6): 758. doi:10.1016/j.ajog.2016.07.012.
[57] Hart RJ. Physiological aspects of female fertility: role of the environment, modern lifestyle, and genetics[J]. Physiol Rev, 2016, 96(3): 873-909.
[58] Fontana L, Partridge L, Longo VD. Extending healthy life span: from yeast to humans[J]. Science, 2010, 328(5976): 321-326.
[59] Luo LL, Chen XC, Fu YC, et al. The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in rats[J]. Aging Clin Exp Res, 2012, 24(2): 125-133.
[60] Rizzoli R, Bischoff-Ferrari H, Dawson-Hughes B, et al. Nutrition and bone health in women after the menopause[J]. Womens Health(Lond), 2014, 10(6): 599-608.
[61] Wang HD, Chen HT, Qin YY, et al. Risks associated with premature ovarian failure in Han Chinese women[J]. Reprod Biomed Online, 2015, 30(4): 401-407.
[62] Tournaire C, Croux S, Maurette MT, et al. Antioxidant activity of flavonoids: efficiency of singlet oxygen(1 delta g)quenching[J]. J Photochem Photobiol B, Biol, 1993, 19(3): 205-215.
[63] Kong XX, Fu YC, Xu JJ, et al. Resveratrol, an effective regulator of ovarian development and oocyte apoptosis[J]. J Endocrinol Invest, 2011, 34(11): e374-e381.
[64] Ahmad SS, Reinius MA, Hatcher HM, et al. Anticancer chemotherapy in teenagers and young adults: managing long term side effects[J]. BMJ, 2016, 354: i4567. doi: 10.1136/bmj.i4567.
[65] Smith KL, Gracia C, Sokalska A, et al. Advances in fertility preservation for young women with cancer[J]. Am Soc Clin Oncol Educ Book, 2018(38): 27-37.
[66] Collins P, Rosano G, Casey C, et al. Management of cardiovascular risk in the perimenopausal women: a consensus statement of European cardiologists and gynecologists[J]. Climacteric, 2007, 10(6): 508-526.
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