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山东大学学报 (医学版) ›› 2022, Vol. 60 ›› Issue (5): 37-42.doi: 10.6040/j.issn.1671-7554.0.2021.0969

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4例继发性肥大性下橄榄核变性的临床及影像学特点

巩雨1,高震1,王虎清1,杨晶雯2,张桂莲1,展淑琴1,张茹1,吴海琴1   

  1. 1.西安交通大学第二附属医院神经内科, 陕西 西安 710004;2.甘肃省人民医院干部病房神经内科, 甘肃 兰州 730000
  • 发布日期:2022-06-01
  • 通讯作者: 吴海琴. E-mail:whq60@163.com
  • 基金资助:
    国家自然科学基金(81270415)

Clinical and imaging characteristics of 4 cases of secondary hypertrophic olivary degeneration

GONG Yu1, GAO Zhen1, WANG Huqing1, YANG Jingwen2, ZHANG Guilian1, ZHAN Shuqin1, ZHANG Ru1, WU Haiqin1   

  1. 1. Department of Neurology, Second Affiliated Hospital of Xian Jiaotong University, Xian 710004, Shaanxi, China;
    2. Department of Neurology, Gansu Provincial Hospital, Lanzhou 730000, Gansu, China
  • Published:2022-06-01

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摘要： 目的 探讨继发性肥大性下橄榄核变性(HOD)临床及影像学特点,提高临床识别及诊断率。 方法 回顾分析2019年4月至2020年1月收治的4例HOD患者临床资料,归纳临床、影像特点,探讨其发生机制。 结果 4例患者均为继发性HOD,脑干、小脑不同病变在锥体系症状好转的基础上出现锥体外系症状。磁共振(MRI)T2成像示下橄榄核局限性高信号伴体积增大。 结论 脑干、小脑病变可导致继发性肥大性HOD。当锥体系症状平稳时出现锥体外系症状,需考虑HOD,结合影像检查可明确诊断。

关键词: 继发性肥大性下橄榄核变性, 临床特征, 影像学表现

Abstract: Objective To explore the clinical and imaging characteristics of secondary hypertrophic olivary degeneration(HOD)so as to improve the clinical recognition and diagnosis. Methods The clinical and imaging data of 4 patients treated during Apr. 2019 and Jan. 2020 were retrospectively analyzed, and the mechanism was discussed. Results All cases were secondary HOD. Symptoms of extra-vertebral system appeared, while symptoms of pyramidal system in different lesions of the brainstem and cerebellum were stable. Limited high signal was observed in the enlarged inferior olivary nucleus on T2WI imaging. Conclusion Variant lesions in brain stem or cerebellum may lead to the occurrence of secondary HOD. When extra-vertebral system symptoms appear in addition to stable vertebral system symptoms, HOD should be considered. A clear diagnosis requires appropriate imaging examinations.

Key words: Secondary hypertrophic olivary degeneration, Clinical manifestation, Imaging characteristics

中图分类号: 

  • R742
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