糖皮质激素性骨质疏松症研究进展

doi:10.6040/j.issn.1671-7554.0.2021.0481

摘要/Abstract

摘要： 糖皮质激素广泛用于治疗各种过敏性和自身免疫性疾病。糖皮质激素性骨质疏松症(GIOP)是长期应用糖皮质激素的不良反应之一,其特征是持续性骨形成下降,伴骨吸收增加,导致骨折发生率增加,给患者带来严重危害。本文对GIOP的发病机制和防治药物进行综述,旨在提高临床医生对GIOP的重视。

关键词: 糖皮质激素, 骨质疏松症, 成骨细胞, 破骨细胞

Abstract: Glucocorticoids are widely used in the treatment of allergic and autoimmune diseases. Glucocorticoid-induced osteoporosis(GIOP)is one of the adverse reactions of long-term application of glucocorticoids, which is characterized by continuous decrease of bone formation accompanied by increase of bone resorption, leading to increased incidence of fracture and bringing serious harm to patients. Herein, we review the pathogenesis of GIOP and its prevention and treatment drugs, in order to raise the attention of clinicians to GIOP.

Key words: Glucocorticoids, Osteoporosis, Osteoblast, Osteoclast

中图分类号:

R574

陈诗鸿. 糖皮质激素性骨质疏松症研究进展[J]. 山东大学学报 (医学版), 2021, 59(6): 33-37.

CHEN Shihong. Progress in glucocorticoid-induced osteoporosis[J]. Journal of Shandong University (Health Sciences), 2021, 59(6): 33-37.

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