菌毛蛋白V型与正畸患者牙龈炎性反应的相关性

doi:10.6040/j.issn.1671-7554.0.2016.481

山东大学学报（医学版） ›› 2017, Vol. 55 ›› Issue (3): 59-63.doi: 10.6040/j.issn.1671-7554.0.2016.481

菌毛蛋白V型与正畸患者牙龈炎性反应的相关性

孙菲¹,李淑香²,王琳^1,3,张丽³,肖水清^1,3

1.滨州医学院口腔学院, 山东滨州 256603;2.济南市章丘区人民医院口腔科, 山东济南 250200;3.济南市口腔医院正畸科, 山东济南 250001

收稿日期:2016-02-02 出版日期:2017-03-10 发布日期:2017-03-10
通讯作者: 肖水清. E-mail:shqxiao@126.com E-mail:shqxiao@126.com
基金资助:
济南市科技局企业创新计划(201121038)

Correlation between porphyromonas gingivalis FimA genotype V and ginival inflammatory in the orthodontic patients

SUN Fei¹, LI Shuxiang², WANG Lin^1,3, ZHANG Li³, XIAO Shuiqing^1,3

1. College of Dentistry, Binzhou Medical University, Binzhou 256603, Shandong, China;
2. Department of Stomatology, Zhangqiu Peoples Hospital, Jinan 250200, Shandong, China;
3. Department of Orthodontics, Jinan Stomatological Hospital, Jinan 250001, Shandong, China

Received:2016-02-02 Online:2017-03-10 Published:2017-03-10

摘要/Abstract

摘要： 目的探讨牙龈卟啉单胞菌(P.g)的菌毛蛋白(FimA)V亚型基因表达与正畸患者牙龈炎性反应的相关性。方法随机选取61例正畸治疗前牙龈健康的患者,分别收集患者正畸治疗前和戴入矫治器后3个月的龈沟液,用PCR技术检测临床样本中的P.g和FimA V型。结果正畸治疗前与戴入矫治器后3个月的P.g检出率分别是26.23%、73.77%,两者间存在统计学差异(P<0.01);FimA V型的检出率分别是9.84%、26.23%,两者间存在统计学差异(P<0.05)。结论正畸患者在戴入矫治器3个月后,P.g和FimA V型的检出率都与牙龈指数呈现正相关,牙龈指数升高,且FimA V型检出率也随之增加,FimA V型可以引起正畸患者的牙龈炎性反应。

关键词: 正畸治疗, 牙龈炎, FimA V型, 牙龈卟啉单胞菌

Abstract: Objective To explore the correlation between the gene expression of FimA genotype V of Porphyromonas gingivais(P.g)and gingival inflammatory in orthodontic patients. Methods Totally 61 patients with healthy gingiva were randomly selected. Their gingival crevicular fluid(GCF)was collected before and 3 months after orthodontic treatment. The content of P.g and FimA genotype V in the GCF was detected with PCR technique. Results The detection rate of P.g and FimA genotype V were 26.23% vs 73.77%, and 9.84% vs 26.23% before and after orthodontic treatment, showing significant difference(P<0.01, P<0.05). Conclusion Three months after patients wore appliance, the detection rate of P.g and FimA genotype V were positively correlated to gingival inflammation index. The detection rate of FimA genotype V rose with increased gingival index. FimA genotype V can cause gingival inflammatory in orthodontic patients.

Key words: Porphyromonas gingivais, FimA genotype V, Orthodontic treatment, Gingivitis

中图分类号:

R783.5

孙菲,李淑香,王琳,张丽,肖水清. 菌毛蛋白V型与正畸患者牙龈炎性反应的相关性[J]. 山东大学学报（医学版）, 2017, 55(3): 59-63.

SUN Fei, LI Shuxiang, WANG Lin, ZHANG Li, XIAO Shuiqing. Correlation between porphyromonas gingivalis FimA genotype V and ginival inflammatory in the orthodontic patients[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 59-63.

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菌毛蛋白V型与正畸患者牙龈炎性反应的相关性

Correlation between porphyromonas gingivalis FimA genotype V and ginival inflammatory in the orthodontic patients

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