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山东大学学报（医学版） ›› 2016, Vol. 54 ›› Issue (1): 86-91.doi: 10.6040/j.issn.1671-7554.0.2015.535

• 临床医学 • 上一篇    下一篇

东营市某三甲医院纵向体检资料的血清谷丙转氨酶水平与代谢综合征的相关性

肖娟1*, 陈启才2*,张鹏鹏3,陈莉莉4,陈潇潇1,王束玫1   

  1. 1. 山东大学公共卫生学院流行病学系, 山东 济南 250012;
    2. 胜利油田中心医院体检中心, 山东 东营 257000;
    3. 天津市出入境检验检疫局保税区办事处检务科, 天津 300000;
    4. 浙江省疾病预防控制中心营养与食品安全所, 浙江 杭州 310051
  • 收稿日期:2015-05-30 出版日期:2016-01-11 发布日期:2016-01-11
  • 通讯作者: 王束玫. E-mail: wshm@sdu.edu.cn*共同第一作者 E-mail:wshm@sdu.edu.cn

Association between serum alanine transaminase with metabolic syndrome and its components based on a longitudinal health check-up study in Dongying City, China

XIAO Juan1*, CHEN Qicai2*, ZHANG Pengpeng3, CHEN Lili4, CHEN Xiaoxiao1, WANG Shumei1   

  1. 1. Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Health Examination Center, Central Hospital of Shengli Oilfield, Dongying 257000, Shandong, China;
    3. Department of Supervision, Tax-protected Zone Office, Tianjin Entry-Exit Inspection and Quarantine Bureau, Tianjin 300000, China;
    4. Department of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China
  • Received:2015-05-30 Online:2016-01-11 Published:2016-01-11

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摘要： 目的 探讨基线拥有不同代谢综合征(MS,包括高血压、超重或肥胖、高脂血症和高血糖4个组分)组分个数的人群血清谷丙转氨酶(ALT)与MS的关系。 方法 基于东营市某三甲医院纵向体检资料构建2006年1月至2011年12月动态体检队列,选取未患MS且至少有3次完整体检资料的5 122名调查对象纳入基线,并根据研究对象拥有MS组分个数的不同(0~2个)进行分层,建立多因素广义估计方程模型(GEE),分析ALT(四分位数间距)与MS发生的相关性,计算RR值及95%CI。 结果 血清ALT水平的升高与MS及其组分的发生呈正相关。与ALT最低水平组相比,基线有0~2个MS组分的人群ALT最高水平组与MS发生的RR值依次为4.39(2.26~8.52)、6.97(3.37~14.42)和1.93(1.26~2.95),基线0个MS组分和仅有1个MS组分的研究对象高水平血清ALT对MS发生的预测性高于基线有2个MS组分的研究对象。 结论 高水平ALT对MS的发生有一定预测性,并在代谢状况不同的人群中有不同表现,血清ALT水平的升高可能是MS发生的早期标志物。

关键词: 谷丙转氨酶, 代谢综合征, 广义估计方程, 东营市, 动态体检队列

Abstract: Objective To investigate the association of serum alanine aminotransferase(ALT)with metabolic syndrome(MS, including hypertension, obesity, hyperlipidemia and hyperglycemia)categorized by different numbers of MS components at baseline. Methods A dynamic health examination cohort study was conducted during 2006 and 2011, which included 5 122 participants who satisfied two basic rules: being free of MS at 1st health check, and having at least three complete health checks. With generalized estimating equation(GEE)model, multivariable relative risk 山 东 大 学 学 报 (医 学 版)54卷1期 -肖娟,等.东营市某三甲医院纵向体检资料的血清谷丙转氨酶水平与代谢综合征的相关性 \=-(RRs)of time-varying ALT with MS and its components were analyzed. Results Increased serum ALT was positively associated with MS and its components. Compared with Q1, RRs(Q4 of ALT for MS)of participants with 0-2 components at baseline were 4.39(2.26-8.52), 6.97(3.37-14.42)and 1.93(1.26-2.95), respectively. Elevated ALT showed stronger predictability for MS in participants with 0 or 1 component of MS than participants with 2 components. Conclusion Elevated serum ALT is an early biomarker of MS and its components. Especially, it may increase the risk of MS in participants with 0 or 1 component of MS.

Key words: Alanine aminotransferase, Generalized estimating equation, Dynamic health examination cohort, Metabolic syndrome, Dongying City

中图分类号: 

  • R589.1
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