小野寺指数在老年食管癌放射治疗中的临床应用

doi:10.6040/j.issn.1671-7554.0.2014.718

摘要/Abstract

摘要： 目的探讨小野寺预后营养指数(以下简称小野寺指数)在老年食管癌放射治疗中的临床应用价值。方法选取山东大学齐鲁医院放疗科2011年1月~2014年6月单纯放射治疗的老年食管鳞癌患者93例,根据患者入院后首次血常规和生化检查结果,计算小野寺指数[小野寺指数=白蛋白值(g/L)+5×淋巴细胞总数(×10⁹/L)],并根据小野寺指数将患者分为营养良好组(小野寺指数≥45)和营养不良组(小野寺指数<45),比较两组患者的临床病理特征、生活质量、放射性食管炎分级和肿瘤退缩速度。结果小野寺指数与老年食管癌患者的肿瘤大小(P=0.002)、远处转移(P=0.024)密切相关;生活质量,尤其是治疗态度(P=0.036)、进食量(P=0.043)、日常生活自理能力(P=0.028)方面,营养良好组明显优于营养不良组;营养不良组放射性食管炎的分级显著高于营养良好组(P=0.032);两组肿瘤退缩速度的差异性尚未达到统计学意义(P>0.05)。结论小野寺指数能较好地反映老年食管癌患者放疗前的营养状态、临床病理特征及放疗并发症发生的情况,是一个较有价值的食管癌放疗评估指标。

关键词: 放射治疗, 老年人, 小野寺预后营养指数, 食管肿瘤

Abstract: Objective To explore the applicative value of Onodera prognostic nutrition index (Onodera index) in elderly patients with esophageal carcinoma treated with radiotherapy. Methods Onodera index of 93 elderly patients with esophageal squamous-cell carcinoma treated with only radiotherapy were collected, and the patients were divided into good-nourishment group (Onodera index ≥45) and poor-nourishment group (Onodera index <45). Correlations between Onodera index and clinicopathological features, quality of life, radiation esophagitis and tumor regression were analyzed. Results Onodera index was found to be related to tumor size (P=0.002) and distant metastases (P=0.024). Good-nourishment group had significantly better quality of life especially therapeutic attitude (P=0.036), food intake (P=0.043) and self-care ability (P=0.028) than poor-nourishment group. Patients in poor-nourishment group had significantly more serious radiation esophagitis than those in good-nourishment group (P=0.032), while there was no significant difference in tumor regression between the two groups (P>0.05). Conclusion Onodera index is a valuable clinical indicator to estimate the nutritional status, clinicopathological features and early complications of elderly esophageal carcinoma patients treated with radiotherapy.

Key words: Elderly patients, Onodera prognostic nutrition index, Esophageal carcinoma, Radiotherapy

中图分类号:

R735.1

杨圣思, 程玉峰. 小野寺指数在老年食管癌放射治疗中的临床应用[J]. 山东大学学报（医学版）, 2015, 53(6): 54-57.

YANG Shengsi, CHENG Yufeng. Application of Onodera prognostic nutrition index in elderly patients with esophageal carcinoma treated with radiotherapy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(6): 54-57.

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