济南市某医院健康查体人群代谢综合征与血清胆红素的相关性

doi:10.6040/j.issn.1671-7554.0.2013.518

山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (3): 101-105.doi: 10.6040/j.issn.1671-7554.0.2013.518

济南市某医院健康查体人群代谢综合征与血清胆红素的相关性

刘聪聪1，祝筠2，宋翠玲3，刘平4

1.山东大学护理学院，山东济南 250012； 2.山东大学附属省立医院，山东济南 250021；
3.山东大学附属省立医院健康查体中心，山东济南 250021； 4.山东大学公共卫生学院，山东济南 250012

收稿日期:2013-08-26 出版日期:2014-03-10 发布日期:2014-03-10
通讯作者: 祝筠。 E-mail：zhuyunzhu@hotmail.com

Relationship between metabolic syndrome and serum bilirubin in asymptomatic population of Jinan, China

LIU Congcong1, ZHU Yun2, SONG Cuiling3, LIU Ping4

1. School of Nursing, Shandong University, Jinan 250012, Shandong， China;
2. Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong， China;
3. Physical Examination Center, Shandong Provincial Hospital Affiliated to Shandong University,
Jinan 250021, Shandong， China;
4. School of Public Health, Shandong University, Jinan 250012, Shandong， China

Received:2013-08-26 Online:2014-03-10 Published:2014-03-10

摘要/Abstract

摘要：

目的调查山东省济南市某三甲医院健康查体人群代谢综合征(MS)的发生风险与血清胆红素的相关性。方法 2012年1月至2012年9月对在山东大学附属省立医院健康查体中心健康查体的人群进行问卷调查、体格检查和实验室检查。运用Pearson相关及多元Logistic回归分析血清胆红素与MS及其各组分之间的相关性。结果资料完整的4896人中，MS的总发生率为10.7%，男性高于女性(13.1% vs 7.2%， χ2=44.486，P<0.001)。MS组直接胆红素(DBIL)浓度低于非代谢综合征 (NMS)组［男性(2.55±0.78)μmol/L vs (2.79±0.92)μmol/L，P<0.01；女性(2.09±0.84)μmol/L vs (2.29±0.85)μmol/L，P<0.01)］，两组总胆红素和间接胆红素差异无统计学意义(P>0.05 )。偏相关分析表明，DBIL与体质量指数、空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白呈负相关(P<0.05)，与高密度脂蛋白呈正相关(P<0.001)。多元Logistic回归显示，调整年龄、饮酒、尿酸、AST、ALT、GGT后，女性DBIL与MS的相关性变弱，男性DBIL与MS发生风险呈负相关。与DBIL水平最高四分位数Q4组相比，男性Q1～Q3组MS的发生风险OR(95%CI)分别为1.7(1.2~2.4)、1.7(1.2~2.3)、1.3(1.0~1.8)，女性分别为1.3(0.6~2.8)、1.3(0.6~2.9)、1.3(0.6~3.0)。结论男性健康查体人群MS的发生风险与血清DBIL呈负相关。

关键词: 代谢综合征, 胆红素, 健康查体

Abstract:

Objective To investigate the association between serum bilirubin and metabolic syndrome (MS) of asymptomatic populations in one tertiary hospital of Jinan, Shandong Province, China. Methods A total of 4896 subjects who came to Shandong Provincial Hospital Affiliated to Shandong University for routine health check-up from January 2012 to September 2012 were enrolled in this study. Demographic information was collected by questionnaire. The data of physical examination and laboratory test were collected. Pearson correlation analysis and logistic regression analysis were performed in order to find out the relationship between serum bilirubin and MS (components). Results The prevalence rate of MS was 10.7% and it was higher in males than in females(13.1% vs 7.2%， χ2 =44.486，P<0.001).The fasting direct bilirubin (DBIL) levels were lower in both males and females with MS than in those without MS ［(2.55±0.78)μmol/L vs (2.79±0.92)μmol/L for males and (2.09±0.84)μmol/L vs (2.29±0.85)μmol/L for females, P<0.01］. Total bilirubin and indirect bilirubin levels had no significant differences between the two groups. Partial correlation analysis found that DBIL was inversely related with BMI, fasting serum glucose, triglyceride, total cholesterol and LDL-C(P<0.05). It also found that DBIL was positively related with HDL-C (P<0.001). After adjustment for age, alcohol intake, uric acid, AST, ALT and GGT, the significance of inverse association between DBIL and MS became attenuated in females while was still consistent in males. Odds ratios (95% confidence intervals) of the lowest, 2nd and 3rd quartiles of DBIL compared with the highest quartile were 1.7(1.2-2.4), 1.7(1.2-2.3) and 1.3(1.0-1.8) in males and 1.3(0.6-2.8), 1.3(0.6-2.9) and 1.3(0.6-3.0) in females respectively. Conclusion The prevalence of MS is inversely correlated with fasting DBIL among asymptomatic male population.

Key words: Bilirubin, Metabolic syndrome, Routine check-up

中图分类号:

刘聪聪1，祝筠2，宋翠玲3，刘平4. 济南市某医院健康查体人群代谢综合征与血清胆红素的相关性[J]. 山东大学学报（医学版）, 2014, 52(3): 101-105.

LIU Congcong1, ZHU Yun2, SONG Cuiling3, LIU Ping4. Relationship between metabolic syndrome and serum bilirubin in asymptomatic population of Jinan, China[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(3): 101-105.

参考文献

相关文章 15

[1]	扈艳雯,王志媛,郁万江,赵蕙琛,韩合理,徐志鹏,马红,张玉超,刘元涛. 52例肥胖患者脂肪分布与代谢综合征及糖代谢指标的相关性[J]. 山东大学学报 (医学版), 2020, 1(8): 101-106.
[2]	孙苑潆,杨亚超,曲明苓,陈雁敏,李敏,王淑康,薛付忠,刘云霞. 健康管理人群代谢综合征发病风险预测模型[J]. 山东大学学报（医学版）, 2017, 55(6): 87-92.
[3]	于珍珍,陈慧,杨晓云,吕明. 高尿酸血症、幽门螺杆菌感染与代谢综合征的相关性[J]. 山东大学学报（医学版）, 2017, 55(5): 76-80.
[4]	许艺博,季晓康,李向一,申振伟,薛付忠. 尿液pH与代谢综合征的相关性[J]. 山东大学学报（医学版）, 2016, 54(12): 82-85.
[5]	肖娟, 陈启才,张鹏鹏,陈莉莉,陈潇潇,王束玫. 东营市某三甲医院纵向体检资料的血清谷丙转氨酶水平与代谢综合征的相关性[J]. 山东大学学报（医学版）, 2016, 54(1): 86-91.
[6]	张风雷, 郑曼, 张琦, 顾磊, 徐新生. 代谢综合征与P波离散度关系的探讨[J]. 山东大学学报（医学版）, 2015, 53(2): 52-55.
[7]	刘剑敏. 茵栀黄注射液灌肠联合培菲康口服治疗新生儿黄疸的疗效观察[J]. 山东大学学报（医学版）, 2014, 52(S1): 57-58.
[8]	王光亚, 郭宁宁, 赵乃蕊, 李瑞杰, 高书明. 脂联素水平在2型糖尿病和甲状腺疾病中的变化及意义[J]. 山东大学学报（医学版）, 2014, 52(S1): 96-97.
[9]	靳成伟, 李葵, 赵静, 岳欣, 尚嫄嫄, 韩露, 张运, 张薇, 马骁, 钟明. 外周血单核细胞甘油三酯水解酶的表达与代谢综合征的相关性[J]. 山东大学学报（医学版）, 2014, 52(8): 39-42.
[10]	贾堂宏1，侯廷成1，谢忠元1，窦克宏1，张济2，边学峰2，时延申3，牛纪伦4，杨华5. 济南市社区人群代谢综合征检出率及危险因素调查[J]. 山东大学学报(医学版), 2013, 51(7): 100-106.
[11]	武传龙1，许良银2，侯新国1，赵汝星1，陈丽1. 甲状腺功能与肥胖及代谢综合征的相关性分析[J]. 山东大学学报(医学版), 2013, 51(12): 88-91.
[12]	孙超1，2, 解双双2, 肖迪2, 刘彩霞1,2, 于进红2, 刘莉2, 李强2. 急性乙型肝炎伴严重高胆红素血症的危险因素[J]. 山东大学学报(医学版), 2012, 50(8): 88-.
[13]	韩露1，王彬2，牟晓梅2，巩会平3，闫会敏1，王志浩1，张运1，张薇1，钟明1. 代谢综合征患者心脏损害与脂肪因子变化的临床研究[J]. 山东大学学报(医学版), 2011, 49(9): 63-.
[14]	郭堑，农村立. 异甘草酸镁治疗伴高胆红素血症病毒性肝炎的疗效观察[J]. 山东大学学报(医学版), 2010, 48(8): 103-106.
[15]	闫会敏1，杨静2，巩会平1,3，王志浩1，方宁宁1，王佳1，张薇1，张运1，钟明1. TRB3基因+251A/G多态性与代谢综合征患者左房功能的相关性研究[J]. 山东大学学报(医学版), 2010, 48(7): 69-.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

济南市某医院健康查体人群代谢综合征与血清胆红素的相关性

Relationship between metabolic syndrome and serum bilirubin in asymptomatic population of Jinan, China

PDF (PC)

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

多维度评价

本文评价

推荐阅读 0