ABT-724对自发性高血压大鼠注意定势转移能力的影响

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (12): 15-19.

ABT-724对自发性高血压大鼠注意定势转移能力的影响

曹爱华1，马良2，于琳3，杨秉上1，张昕婷1，雷革非1，王纪文1

1.山东大学齐鲁医院儿童医疗中心，山东大学脑科学研究所，济南 250012；
2.滨州医学院附属医院儿童保健科，山东滨州 256003； 3.杭州市中心医院儿科，杭州 310000

收稿日期:2013-08-27 出版日期:2013-12-10 发布日期:2013-12-10
通讯作者: 雷革非， E-mail: leigefei@sdu.edu.cn; 王纪文， E-mail: wangjiwen99@gmail.com
基金资助:
济南市科技明星计划(20120140)；山东省优秀中青年科学家科研奖励基金(BS2013YY011)；教育部留学归国人员科研启动基金；“泰山学者”建设工程专项经费资助

Effect of ABT-724 on ability of attentional set-shifting in spontaneously hypertensive rats

CAO Ai-hua1, MA Liang2, YU Lin3, YANG Bing-shang1, ZHANG Xin-ting1, LEI Ge-fei1, WANG Ji-wen1

1. Medical Center of Pediatrics, Qilu Hospital of Shandong University, Brain Science Research Institute of
Shandong University, Jinan 250012, China;
2. Department of Child Health Care, the Affiliated Union Hospital of Binzhou Medical College, Binzhou 256003, China;
3. Department of Pediatrics, Hangzhou Central Hospital, Hangzhou 310000, China

Received:2013-08-27 Online:2013-12-10 Published:2013-12-10

摘要/Abstract

摘要：

目的探讨选择性多巴胺D4受体激动剂ABT-724对注意缺陷多动障碍(ADHD)动物模型―自发性高血压大鼠(SHR)注意定势转移能力的影响。方法根据ABT-724的用量(腹腔注射，0.04、0.16、0.64 mg/kg)，将SHR大鼠分为低、中、高剂量组，以哌甲酯组、SHR盐水组及WKY盐水组为对照，采用行为观测的方法，观察该药物对SHR大鼠注意定势转移能力的影响。结果在注意定势转移实验中，低、中、高剂量组与SHR盐水组相比，其循环数、错误数均降低(P<0.01)；与哌甲酯组相比，差异无统计学意义(P>0.05)。错误类型分析结果显示，低、中、高剂量组与SHR盐水组比较，固执错误数和退化错误数均明显降低(P<0.01)，而非强化错误数无改变(P>0.05)；与哌甲酯组相比，差异均无统计学意义(P>0.05)。结论 ABT-724可有效改善SHR大鼠的注意定势转移能力，而且与哌甲酯的效果相当。

关键词: 注意缺陷多动障碍；多巴胺D4受体；ABT-724；自发性高血压大鼠；注意定势转移

Abstract:

Objective To investigate the effects of ABT-724， a selective dopamine D4 receptor， on attentional set-shifting behaviors in spontaneously hypertensive rats (SHR), a rat model of attention-deficit hyperactivity disorder (ADHD). Methods According to the dose of ABT-724 (intraperitoneal injection, 0.04, 0.16 and 0.64mg/kg), SHR rats were divided into three (low, medium and high dose) groups. SHR rats intervened with methylphenidate (25mg/kg) or saline and Wistar-Kyoto (WKY) rats intervened with saline were all taken as control groups, and they were named as methylphenidate group, SHR saline group and WKY saline group, respectively. The effects of ABT-724 on attentional set-shifting behaviors in SHR rats were observed. Results Compared with SHR saline group, the trials and errors to reach criterion were all reduced in low, medium and high dose group (P< 0.01). Compared with methylphenidate group, there was no obvious difference in trials and errors to reach criterion for all the three dose groups (P>0.05). According to the error types, low, medium and high dose groups showed less perseverative and regressive errors than SHR saline group (P<0.01), but showed no obvious difference in never-reinforced error (P>0.05). Compared with methylphenidate group, there was no significant change in error types for all the three doses groups (P>0.05). Conclusion ABT-724 can improve attentional set-shifting behaviors in SHR rats as methylphenidate.

Key words: Attention-deficit hyperactivity disorder; Dopamine D4 receptor; ABT-724; Spontaneously hypertensive rat; Attentional set-shifting

中图分类号:

R748

曹爱华1，马良2，于琳3，杨秉上1，张昕婷1，雷革非1，王纪文1. ABT-724对自发性高血压大鼠注意定势转移能力的影响[J]. 山东大学学报(医学版), 2013, 51(12): 15-19.

CAO Ai-hua1, MA Liang2, YU Lin3, YANG Bing-shang1, ZHANG Xin-ting1, LEI Ge-fei1, WANG Ji-wen1. Effect of ABT-724 on ability of attentional set-shifting in spontaneously hypertensive rats[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(12): 15-19.

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