慢性乙型肝炎患者血清瘦素水平与抗病毒治疗应答的相关性

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (9): 96-99.

慢性乙型肝炎患者血清瘦素水平与抗病毒治疗应答的相关性

张秀珍,刘莉,刘倩

济南市传染病医院肝病科，济南 250021

收稿日期:2012-06-06 出版日期:2012-09-10 发布日期:2012-09-10
作者简介:张秀珍(1965- )，女，副主任医师，主要从事病毒性肝炎抗病毒治疗研究。
基金资助:
济南市卫生局立项课题(2007-680)。

Relativity of serum leptin level and response to antiviral
therapy in patients with chronic hepatitis B

ZHANG Xiu-zhen, LIU Li, LIU Qian

Department of Liver Disease, Jinan Infectious Disease Hospital, Jinan 250021, China

Received:2012-06-06 Online:2012-09-10 Published:2012-09-10

摘要/Abstract

摘要：

目的探讨血清瘦素水平与慢性乙型肝炎(慢乙肝)患者抗病毒治疗持续病毒学应答(sustained virological response， SVR)及不良反应的相关性。方法入组患者均为轻、中度慢乙肝，研究组42例，两对照组为服用核苷(酸)类药物的患者(26例)、健康者(20例)。各组性别、年龄、身高等无统计学差异(P>0.05),具可比性。结果慢乙肝患者血清瘦素水平比健康人群高；研究组患者血清瘦素在治疗12、24周时显著低于基线水平，停药后渐回升；患者基线血清瘦素水平越低SVR率越高(P<0.01)；研究组患者血清瘦素水平与体质量变化明显相关(r=0.996、P=0.004)。结论慢乙肝患者基线血清瘦素水平与抗病毒治疗的SVR相关，是SVR的预测因子之一。α-干扰素治疗过程中血清瘦素水平与体质量变化有明显相关性。

关键词: 慢性乙型肝炎；血清；瘦素；病毒学应答；体质量指数

Abstract:

Objective To study the effects of serum leptin level on sustained virological response(SVR) and adverse reactions in patients with chronic hepatitis B(CHB). Methods Mild and moderate CHB patients were engaged in the study. There were three groups :the study group (n=42), the nucleoside treatment group (n=26) and the healthy control group (n=20). There were no significant differences in age, gender and body height among three groups. Results The serum leptin levels of CHB patients were higher than healthy people. Serum leptin levels of patients in the study group decreased gradually below the baseline at week 12 and 24， then restored after drug withdraw. Patients with SVR had lower serum leptin levels(P<0.01). The serum leptin level was significantly associated with body weight changes in the study group(r=0.996, P=0.004). Conclusion The baseline serum leptin level is associated with SVR in CHB patients and it was a predictor for SVR. The serum leptin level is significantly associated with body weight changes during α-IFN therapy.

Key words: Chronic hepatitis B； Serum； Leptin； Virological response； Body mass index

中图分类号:

R512.6

张秀珍,刘莉,刘倩. 慢性乙型肝炎患者血清瘦素水平与抗病毒治疗应答的相关性[J]. 山东大学学报(医学版), 2012, 50(9): 96-99.

ZHANG Xiu-zhen, LIU Li, LIU Qian. Relativity of serum leptin level and response to antiviral
therapy in patients with chronic hepatitis B[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(9): 96-99.

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