功能性消化不良患者精神心理因素与十二指肠肥大细胞的相关性

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (6): 122-.

功能性消化不良患者精神心理因素与十二指肠肥大细胞的相关性

袁海鹏1,2，李福康2，李改芹2，王晓虹2，李晓沛2，李延青1

1.山东大学齐鲁医院消化内科，济南 250012；
2.山东泰安市中心医院消化内科，山东泰安 27100

收稿日期:2012-02-21 出版日期:2012-06-10 发布日期:2012-06-10
通讯作者: 李延青(1962- )，男，博士，教授，博士生导师，主要从事功能性胃肠病发病机制的研究。 E-mail:mx8902@163. com
作者简介:袁海鹏(1977- )，男，副主任医师，博士研究生，主要从事功能性胃肠病发病机制的研究

Relationship between psychosocial factors and duodenal mast cells in
patients with functional dyspepsia

YUAN Hai-peng1,2， LI Fu-kang2, LI Gai-qin2, WANG Xiao-hong2, LI Xiao-pei2, LI Yan-qing1

1. Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, China;
2. Department of Gastroenterology, Taian City Central Hospital, Taian 271000， Shandong, China

Received:2012-02-21 Online:2012-06-10 Published:2012-06-10

摘要/Abstract

摘要：

目的探讨精神心理因素和十二指肠黏膜肥大细胞(mast cell，MC)在功能性消化不良(functional dyspepsia，FD)中的作用。方法应用医院焦虑抑郁量表(hospital anxiety and depression scale，HADS)评定焦虑(HADS-A)和抑郁积分(HADS-D )，甲苯胺蓝染色计数十二指肠黏膜MC总数及脱颗粒比率。直线相关分析HADSA、HADS-D与十二指肠黏膜MC的相关性。结果 FD患者HADS-A和HADS-D显著高于对照组(P<0.05)，十二指肠黏膜MC显著高于对照组(P<0.01)，MC脱颗粒比率显著高于对照组(P<0.001)。HADS-A、HADS-D与十二指肠MC计数、脱颗粒比率呈正相关(P<0.05)。结论 FD患者的精神心理异常，可能与十二指肠黏膜MC的数目及脱颗粒比率增高有关。

关键词: 功能性消化不良；焦虑；抑郁；十二指肠；肥大细胞

Abstract:

Objective To explore the roles of psychosocial factors and duodenal mast cells in the pathogenesis of functional dyspepsia (FD). Methods The Hospital Anxiety and Depression Scale (HADS) was used to evaluate the psychosocial status of FD patients. Mast cell abundance and degranulation rates in the bulb (D1) and second part (D2) of the duodenum were obtained on toluidine blue-stained sections. The relationships among the scores of anxiety (HADS-A) and depression (HADS-D), the MC counts and MC degranulation rates in D1 and D2 were studied. Results HADS-A and HADS-D scores were significantly higher in FD patients than in controls (P<0.05). This was also true for duodenal mast cell abundance (P<0.01) and degranulation rates (P<0.001). Scores of HADS-A and HADS-D were positively correlated with the duodenal mast cell abundance and degranulation rates. Conclusion The abnormal psychosocial status of FD patients is correlated with the increased abundance and degranulation rates of duodenal mast cells.

Key words: Functional dyspepsia； Anxiety; Depression; Duodenum； Mast cell

中图分类号:

R573.5

袁海鹏1,2，李福康2，李改芹2，王晓虹2，李晓沛2，李延青1. 功能性消化不良患者精神心理因素与十二指肠肥大细胞的相关性[J]. 山东大学学报(医学版), 2012, 50(6): 122-.

YUAN Hai-peng1,2， LI Fu-kang2, LI Gai-qin2, WANG Xiao-hong2, LI Xiao-pei2, LI Yan-qing1. Relationship between psychosocial factors and duodenal mast cells in
patients with functional dyspepsia[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(6): 122-.

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