关键词: 狗；肺疾病，阻塞性；血液流变学；川芎嗪；动物模型

Abstract:

Objective   To investigate the influence of ligustrazine on hemodynamic changes after the acute pulmonary embolism(APE) in canis familiaris. Methods   30 canis familiaris were randomly divided into 2 groups: the control group and the therapeutic group. The model of acute pulmonary embolism was established by injecting sludged blood into the pulmonary artery. Ligustrazine(5mg/Kg) was injected into vein in the therapeutic group with 200ml/h speed 30 minutes after the injection of sludged blood. 5%Glucose was used in the control group the same way as the therapeutic group. Seven phases were set:15minutes before the injection, 0.5hour, 1hour,  2 hours,4 hours,8 hours and12 hours after the injection, recorded as T1,T2,T3，T4，T5，T6 and T7 respectively. The hemodynamics data were observed. Results   Hemodynamic changes were observed after the establishment of acute pulmonary embolism model in canis familiaris. The circumfusion insufficiency of lung microcirculation could result in increases in the blood viscosity,  the restore viscosity, the hematocrit, erythrocyte rigidity index and erythrocyte aggregation index. Ligustrazine could decrease the blood viscosity and the restore viscosity, and restrict the hematocrit, erythrocyte rigidity index and erythrocyte aggregation index. Conclusion   Ligustrazine can improve hemodynamic changes after APE in canis familiaris.

Key words: Dogs; Lung diseases, obstructive; Hemorheology; Ligustrazine; Models animal