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山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (8): 68-71.doi: 10.6040/j.issn.1671-7554.0.2014.067

• 临床医学 • 上一篇    下一篇

磁共振体素内不相干运动在轻度认知功能障碍诊断中的初步研究

董栋1,2, 王新怡3   

  1. 1. 济南大学 山东省医学科学院 医学与生命科学学院, 山东 济南 250001;
    2. 山东省医学科学院, 山东 济南 250062;
    3. 山东大学附属千佛山医院影像科, 山东 济南 250014
  • 收稿日期:2014-02-11 修回日期:2014-06-10 出版日期:2014-08-10 发布日期:2014-08-10
  • 通讯作者: 王新怡。E-mail：wxy_88@163.com E-mail:wxy_88@163.com
  • 基金资助:
    山东省科技发展计划攻关项目（2009GG10002024）；山东省医药卫生科技发展计划项目（2009HW075）

Preliminary study of magnetic resonance intravoxel incoherent motion in the diagnosis of patients with mild cognitive impairment

DONG Dong1,2, WANG Xinyi3   

  1. 1. School of Medcine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250001, Shandong, China;
    2. Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China;
    3. Department of Imaging, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2014-02-11 Revised:2014-06-10 Online:2014-08-10 Published:2014-08-10

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摘要： 目的 探讨轻度认知功能障碍（MCI）患者与认知功能正常的老年人大脑rCBFivim的差异，评估磁共振体素内不相干运动（IVIM）在MCI诊断中的价值。方法 选择2012年7月至2013年5月在山东大学附属千佛山医院神经内科就诊的主诉记忆力减退的患者，分为MCI组和认知正常组（NC组），各20例。进行IVIM扫描，测量双侧额叶、顶叶、颞叶、枕叶和海马区D*和f值，计算rCBFivim值，比较MCI组和NC组的差异。结果 MCI组双侧颞叶、顶叶、额叶、双侧海马区rCBFivim值较NC组降低（P均<0.05）；小脑、枕叶rCBFivim值较NC组降低，但差异无统计学意义（P均>0.05）。结论 IVIM对MCI有一定的诊断意义，可作为评估MCI患者脑血流下降的有效方法。

关键词: 轻度认知功能障碍, 体素内不相干运动, 磁共振灌注成像

Abstract: Objective To investigate the difference of rCBFivim between the aged people who suffered mild cognitive impairment (MCI) and who showed normal cognition, and to evaluate the value of the intravoxel incoherent motion(IVIM) in the diagnosis of MCI. Methods The patients who visited the Neurology Department of Qianfoshan Hospital Affiliated to Shandong University from July 2012 to May 2013 with complaints of memory loss were enrolled in this study. Twenty MCI patients(MCI group) and 20 individuals with normal cognition(NC group) were performed IVIM detection. The values of D* and f were measured in the areas of both sides of frontal, parietal, occipital lobe, temporal lobe and hippocampus, followed by the calculation of rCBFivim. Results Compared with NC group, rCBFivim significantly decreased in the frontal, parietal, temporal lobe and the area of hippocampus in MCI group (all P<0.05). Compared with NC group, rCBFivim of MCI group also decreased in the cerebellum and occipital lobe, which showed no statistical difference(all P>0.05). Conclusion The intravoxel incoherent motion technique is helpful for the diagnosis of MCI, and it is an useful tool for the assessment of cerebral blood flow in patients with MCI.

Key words: Intravoxel incoherent motion, Magnetic resonance perfusion imaging, Mild cognitive impairment

中图分类号: 

  • R574
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