您的位置：山东大学 -> 科技期刊社 -> 《山东大学学报（医学版）》

山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (8): 68-71.doi: 10.6040/j.issn.1671-7554.0.2014.067

• 临床医学 • 上一篇    下一篇

磁共振体素内不相干运动在轻度认知功能障碍诊断中的初步研究

董栋1,2, 王新怡3   

  1. 1. 济南大学 山东省医学科学院 医学与生命科学学院, 山东 济南 250001;
    2. 山东省医学科学院, 山东 济南 250062;
    3. 山东大学附属千佛山医院影像科, 山东 济南 250014
  • 收稿日期:2014-02-11 修回日期:2014-06-10 出版日期:2014-08-10 发布日期:2014-08-10
  • 通讯作者: 王新怡。E-mail：wxy_88@163.com E-mail:wxy_88@163.com
  • 基金资助:
    山东省科技发展计划攻关项目（2009GG10002024）；山东省医药卫生科技发展计划项目（2009HW075）

Preliminary study of magnetic resonance intravoxel incoherent motion in the diagnosis of patients with mild cognitive impairment

DONG Dong1,2, WANG Xinyi3   

  1. 1. School of Medcine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250001, Shandong, China;
    2. Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China;
    3. Department of Imaging, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2014-02-11 Revised:2014-06-10 Online:2014-08-10 Published:2014-08-10

PDF (PC)

134

摘要： 目的 探讨轻度认知功能障碍（MCI）患者与认知功能正常的老年人大脑rCBFivim的差异，评估磁共振体素内不相干运动（IVIM）在MCI诊断中的价值。方法 选择2012年7月至2013年5月在山东大学附属千佛山医院神经内科就诊的主诉记忆力减退的患者，分为MCI组和认知正常组（NC组），各20例。进行IVIM扫描，测量双侧额叶、顶叶、颞叶、枕叶和海马区D*和f值，计算rCBFivim值，比较MCI组和NC组的差异。结果 MCI组双侧颞叶、顶叶、额叶、双侧海马区rCBFivim值较NC组降低（P均<0.05）；小脑、枕叶rCBFivim值较NC组降低，但差异无统计学意义（P均>0.05）。结论 IVIM对MCI有一定的诊断意义，可作为评估MCI患者脑血流下降的有效方法。

关键词: 轻度认知功能障碍, 体素内不相干运动, 磁共振灌注成像

Abstract: Objective To investigate the difference of rCBFivim between the aged people who suffered mild cognitive impairment (MCI) and who showed normal cognition, and to evaluate the value of the intravoxel incoherent motion(IVIM) in the diagnosis of MCI. Methods The patients who visited the Neurology Department of Qianfoshan Hospital Affiliated to Shandong University from July 2012 to May 2013 with complaints of memory loss were enrolled in this study. Twenty MCI patients(MCI group) and 20 individuals with normal cognition(NC group) were performed IVIM detection. The values of D* and f were measured in the areas of both sides of frontal, parietal, occipital lobe, temporal lobe and hippocampus, followed by the calculation of rCBFivim. Results Compared with NC group, rCBFivim significantly decreased in the frontal, parietal, temporal lobe and the area of hippocampus in MCI group (all P<0.05). Compared with NC group, rCBFivim of MCI group also decreased in the cerebellum and occipital lobe, which showed no statistical difference(all P>0.05). Conclusion The intravoxel incoherent motion technique is helpful for the diagnosis of MCI, and it is an useful tool for the assessment of cerebral blood flow in patients with MCI.

Key words: Intravoxel incoherent motion, Magnetic resonance perfusion imaging, Mild cognitive impairment

中图分类号: 

  • R574
[1] Petersen R C, Doody R, Kurz A, et al. Current concepts in mild cognitive impairment[J]. Arch Neurol, 2001, 58(12):1985-1992.
[2] Nobili F, Mazzei D, Dessi B, et al. Unawareness of memory deficit in amnestic MCI: FDG-PET findings[J]. J Alzheimers Dis, 2010, 22(3):993-1003.
[3] Binnewijzend M A, Kuijer J P, Benedictus M R, et al. Cerebral blood flow measured with 3D pseudocontinuous arterial spin-labeling MR imaging in Alzheimer disease and mild cognitive impairment: a marker for disease severity[J]. Radiology, 2013, 267(1):221-230.
[4] Albert M S, DeKosky S T, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease[J]. Alzheimers Dement, 2011, 7(3):263-269.
[5] Moore R J, Issa B, Tokarczuk P, et al. In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T[J]. Magn Reson Med, 2000, 43(2):295-302.
[6] Morvan D. In vivo measurement of diffusion and pseudo-diffusion in skeletal muscle at rest and after exercise[J]. Magn Reson Imaging, 1995, 13(2):193-199.
[7] Le Bihan D, Breton E, Lallemand D, et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders[J]. Radiology, 1986, 161(2):401-407.
[8] Koh D M, Collins D J, Orton M R. Intravoxel incoherent motion in body diffusion-weighted MRI: reality and challenges[J]. AJR Am J Roentgenol, 2011, 196(6):1351-1361.
[9] Sasaki M, Sumi M, Van Cauteren M, et al. Intravoxel incoherent motion imaging of masticatory muscles: pilot study for the assessment of perfusion and diffusion during clenching[J]. AJR Am J Roentgenol, 2013, 201(5):1101-1107.
[10] Wirestam R, Borg M, Brockstedt S, et al. Perfusion-related parameters in intravoxel incoherent motion MR imaging compared with CBV and CBF measured by dynamic susceptibility-contrast MR technique[J]. Acta Radiol, 2001, 42(2):123-128.
[11] Torre J C. Impaired cerebromicrovascular perfusion: summary of evidence in support of its causality in Alzheimer's disease[J]. Ann N Y Acad Sci, 2000, 924:136-152.
[12] Dai W, Lopez O L, Carmichael O T, et al. Mild cognitive impairment and Alzheimer disease: patterns of altered cerebral blood flow at MR imaging1[J]. Radiology, 2009, 250(3):856-866.
[13] Alegret M, Cuberas-Borrós G, Vinyes-Junqué G, et al. A two-year follow-up of cognitive deficits and brain perfusion in mild cognitive impairment and mild Alzheimer's disease[J]. J Alzheimers Dis, 2012, 30(1):109-120.
[14] Alsop D C, Casement M, de Bazelaire C, et al. Hippocampal hyperperfusion in Alzheimer's disease[J]. Neuroimage, 2008, 42(4):1267-1274.
[15] 丁蓓，张泳，凌华威，等. 基于体素的动脉自旋标记成像在遗忘型轻度认知障碍患者脑血流灌注中的应用研究[J]. 临床放射学杂志, 2013, 32(1):6-10.
[1] 俞璐,刘强. 体素内不相干运动磁共振成像对糖尿病患者肾脏功能的评价作用[J]. 山东大学学报（医学版）, 2016, 54(11): 68-71.
[2] 赵强，康永军，王新怡，杨志强. 轻度认知功能障碍患者海马区的磁共振弥散张量成像分析[J]. 山东大学学报(医学版), 2012, 50(3): 103-.
[3] 孟媛媛，单培彦，刘爱芬，麻琳，程梅,戴廷军. 老年患者代谢综合征与轻度认知功能障碍的相关性研究[J]. 山东大学学报(医学版), 2010, 48(2): 14-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
版权所有 © 2018 《山东大学学报(医学版)》编辑部　
地址:山东大学科技期刊社（济南市历城区山大南路27号山东大学中心校区明德楼B座721室） 电话: 0531-88366918 E-mail: xbyxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发