Abstract: To explore the relationship between genetic polymorphisms of CYP17 MspA1I and cirrhosis or hepatocellular carcinoma in hepatitis B infected patients of Shandong Province. Methods80 healthy controls and 376 HBV patients including 96 hepatocelluar carcinomas(HCC), 107 cirrhosis, 82 hepatitis and 91 HBsAg carriers were determined the T→C in CYP17 MspA1I by polymerase chain reaction and restriction fragment length polymorphism (PCRRFLP). ResultsCompared with the carriers, the (-34) A2/A2 genotype of CYP17 significantly increased the risks of HCC patients. Females mostly contributed to this association (OR＝5.93, P＝0.002), and the OR values increased in postmenopausal women (OR＝6.18, P＝0.003) but not in male subjects. There were no significant differences in the distribution of CYP 17 genotypes between carriers and cirrhosis (P>0.05). ConclusionCYP17 MspA1I genotypes A2/A2 may be related to liver cancer risk in HBVinfected women in Shandong Province.

Key words: Hepatitis B virus, Carcinoma, hepatocellular,