羟苯磺酸钙治疗早期糖尿病肾病的疗效观察

山东大学学报(医学版)

羟苯磺酸钙治疗早期糖尿病肾病的疗效观察

董静¹，梁翠格²，张晓倩³，李明龙¹，刘占峰¹，赵家军¹，于桂娜¹

1. 山东大学附属省立医院内分泌科，济南 250021； 2. 山东省临沂市人民医院内分泌科，山东临沂 276003；3. 山东省千佛山医院内分泌科，济南 250014

收稿日期:2007-08-24 修回日期:1900-01-01 出版日期:2008-01-16 发布日期:2008-01-16
通讯作者: 于桂娜

Calcium dobesilate in the treatment of early diabetic nephropathy

DONG Jing¹，LIANG Cui-ge²，ZHANG Xiao-qian³，LI Ming-long¹，LIU Zhan-feng¹，ZHAO Jia-jun¹，YU Gui-na¹

Department of Endocrine, 1. Provincial Hospital affiliated to Shandong University, Jinan 250021, China;2. Linyi People′s Hospital, Linyi 276003, Shandong, China; 3. Shandong Qianfoshan Hospital

Received:2007-08-24 Revised:1900-01-01 Online:2008-01-16 Published:2008-01-16
Contact: YU Gui-na

摘要/Abstract

摘要： 目的观察羟苯磺酸钙治疗早期糖尿病肾病的临床疗效。方法早期糖尿病肾病患者42例，随机分成两组：对照组，21例，常规降糖治疗；治疗组，21例，常规降糖加用羟苯磺酸钙500mg tid治疗，疗程12周。观察治疗前后24h尿白蛋白排出量（UAE）、血浆内皮素（ET）、血清一氧化氮（NO）、空腹血糖、餐后2h血糖、糖化血红蛋白、肝肾功能的变化。结果治疗组治疗后，UAE显著降低（P＜0.01)，ET降低，NO升高；空腹血糖、餐后2h血糖、糖化血红蛋白、肝肾功能差异无统计学意义。对照组治疗后，UAE、ET、NO、空腹血糖、糖化血红蛋白、肝肾功能差异无统计学意义。结论羟苯磺酸钙能减少早期糖尿病肾病患者的尿白蛋白排泄，延缓糖尿病肾病的进展；并通过降低血浆ET、增加血清NO以实现对肾脏的保护作用。

Abstract: To investigate the clinical effects of calcium dobesilate on early diabetic nephropathy. Methods42 patients with early diabetic nephropathy were randomly divided into the treatment and control groups. All the patients were given treatment to control blood glucose and 21 patients in the treatment group were treated with calcium dobesilate (500?mg, three times per day) for 12 weeks. Urinary albumin excretion, plasma endothelin, serum nitric oxide, serum glucose, glycosylated heamoglobin A1c, hepatic and renal function were determined before and after the treatment. ResultsAfter 12 weeks of treatment, in the treatment group the levels of UAE were significantly decreased（P＜0.01), the levels of ET were decreased, the levels of NO were increased, and the levels of serum glucose and HbA1c had no changes. However, the levels of UAE, ET, NO, serum glucose and HbA1c had no changes in the control group. ConclusionCalcium dobesilate can decrease the levels of UAE in patients with early diabetic nephropathy and postpone the development of diabetic nephropathy, which may be due to its correction of abnormal renal hemodynamics through decreasing ET and increasing NO.

Key words: Diabetic nephropathy, Calcium dobesilate, Endothelin, Nitric oxide

中图分类号:

R587.2

董静,梁翠格,张晓倩,李明龙,刘占峰,赵家军,于桂娜 . 羟苯磺酸钙治疗早期糖尿病肾病的疗效观察[J]. 山东大学学报(医学版), 2008, 46(1): 80-83.

DONG Jing,LIANG Cui-ge,ZHANG Xiao-qian,LI Ming-long,LIU Zhan-feng,ZHAO Jia-jun,YU Gui-na. Calcium dobesilate in the treatment of early diabetic nephropathy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(1): 80-83.

参考文献

相关文章 15

[1]	巩璐伟,周丽珍,苏国海. 培哚普利通过调节Akt-FoxO1通路保护糖尿病性心肌病大鼠心功能损伤[J]. 山东大学学报（医学版）, 2017, 55(10): 65-70.
[2]	赵蕙琛,柴家超,张亮,袁明振,彭力,刘元涛. 糖尿病大鼠阴茎海绵体硫化氢含量及其合成酶表达的变化[J]. 山东大学学报（医学版）, 2016, 54(10): 25-28.
[3]	陈志新,王颖,曹新冉, 黑乃豪,李俊龙,董波,关广聚. 非肽类Ang(1-7)受体激动剂AVE0991对大鼠糖尿病肾病的保护作用[J]. 山东大学学报（医学版）, 2016, 54(10): 29-33.
[4]	史蕊,孙佩,王璐璐,丁琳,夏金,王燕,逄曙光. 鼠神经生长因子联合维生素D、甲钴胺治疗糖尿病周围神经病变的临床观察[J]. 山东大学学报（医学版）, 2016, 54(4): 64-67.
[5]	毕大鹏1，嵇高德1，张洪星2 . 通心络胶囊对早期糖尿病肾病患者胱抑素C的影响[J]. 山东大学学报(医学版), 2013, 51(7): 67-69.
[6]	周雁1,郭立新1,周璐2，汪耀1，牟忠卿1，王晓霞1，于冬妮1，张丽娜11,周璐2，汪耀1，牟忠卿1，王晓霞1，于冬妮1，张丽娜1. 老年2型糖尿病患者周围神经病变的影响因素[J]. 山东大学学报(医学版), 2012, 50(6): 1-4.
[7]	王倩1,张莹1,侯为开1,张莉2,徐华3,王鹏4,于珊1, 刘骞1,黄庆先1. 2型糖尿病性腹泻与肠神经系统病变关系的探讨[J]. 山东大学学报(医学版), 2011, 49(8): 13-.
[8]	孔德焕1，于进堂2，高美娟1，李波1，卞丽香1，李明龙3，刘明4，于桂娜1. 羟苯磺酸钙对糖尿病大鼠主动脉的保护作用[J]. 山东大学学报(医学版), 2010, 48(10): 4-.
[9]	侯亮，刘雪平，袁树华，王美霞，徐松. 胰岛素抵抗大鼠血管AGEs水平及其损伤机制和吡格列酮的保护作用[J]. 山东大学学报(医学版), 2010, 48(4): 5-9.
[10]	张月华，赵新国，岳玉国，吕英俊. 诺和锐30特充强化治疗初诊2型糖尿病疗效观察[J]. 山东大学学报(医学版), 2010, 48(4): 160-.
[11]	李文斌1，崔美玉1，许冬梅1，关广聚2. 二基肽酶IV酶活性与糖尿病肾病的相关性[J]. 山东大学学报(医学版), 2010, 48(3): 12-14.
[12]	李倩，汪翼，孙书珍，陈瑶，王立俊. 糖尿病大鼠心肌胶原代谢的变化及与MMP-2/TIMP-2表达的关系[J]. 山东大学学报(医学版), 2010, 48(3): 1-6.
[13]	. 2，5二羟苯磺酸钙对糖尿病大鼠心肌保护作用的研究[J]. 山东大学学报(医学版), 2009, 47(10): 9-14.
[14]	李宪花高海青李保应程梅许玲胡昭. 葡萄子原花青素对糖尿病肾病大鼠非酶糖基化终产物和骨形态蛋白7表达的影响[J]. 山东大学学报(医学版), 2009, 47(5): 16-22.
[15]	孙洁任建民陈超刘昌盛司庆盈. 糖尿病合并冠心病与白蛋白尿的相关性研究[J]. 山东大学学报(医学版), 2009, 47(5): 102-105.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed