关键词: 充血性心力衰竭；抵抗素；基质金属蛋白酶2；N端脑钠肽；左心室射血分数；左心室短轴缩短率

Abstract:

Objective    To study concentration changes of serum resistin, matrix metalloproteinases-2(MMP-2) and N-terminal fragment of the pro-peptide of brain natriuretic peptide (NT-ProBNP) in patients with congestive heart failure(CHF), and the relationship with the left ventricular function. Methods    78 CHF patients and 30 healthy controls were selected, and serum resistin and MMP-2 were detected by ELISA and NT-ProBNP with the electrochemistry luminescence method. Left ventricular function parameters were measured at the same time: left ventricular end-diastolic dimension(LVEDD), left ventricular end-systolic dimension(LVESD), left ventricular ejection fraction(LVEF) and left ventricular fractional shortening(LVFS). Results    Serum resistin, MMP-2 and NT-ProBNP levels in patients with CHF were higher than those in the healthy controls(P＜0.05), and evidently increased with cardiac function improvement(P＜0.05). Serum resistin, MMP-2 and NT-ProBNP levels were positively related with LVEDD and LVESD, negatively related with LVEF and LVFS(P＜0.05). Conclusion     Resistin, MMP-2 and NT-ProBNP play a very important role in CHF, and are useful in the early diagnosis and evaluation of cardiac function of CHF patients.