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山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (7): 69-.

• 论文 • 上一篇    下一篇

TRB3基因+251A/G多态性与代谢综合征患者左房功能的相关性研究

闫会敏1,杨静2,巩会平1,3,王志浩1,方宁宁1,王佳1,张薇1,张运1,钟明1   

  1. 1.山东大学齐鲁医院心内科, 教育部和卫生部心血管重构和功能研究重点实验室, 济南 250012;
    2.山东威海市立医院保健科, 山东 威海 264200; 3.青岛大学医学院附属医院特需保健科, 山东 青岛 266003
  • 收稿日期:2010-04-12 出版日期:2010-07-16 发布日期:2010-07-16
  • 通讯作者: 钟明(1968- ),女,博士,教授,硕士生导师,主要从事代谢综合征和糖尿病心血管并发症的基础和临床研究。 Email: zhongming2@medmail.com.cn
  • 作者简介:闫会敏(1983- ),女,硕士研究生,主要从事代谢综合征和高胆固醇血症的基础和临床研究。 Email:yanhuimin830516@163.com
  • 基金资助:

    国家自然科学基金资助项目(30871038、30971215);山东省自然科学基金资助项目(ZR2009CM025、Y2005C11);山东省科技攻关计划资助项目(2006GG2202020)

Association of TRB3 +251A/G polymorphism with left atrial dysfunction in patients with metabolic syndrome

YAN Huimin1, YANG Jing2, GONG Huiping1,3, WANG Zhihao1, FANG Ningning1,WANG Jia1, ZHANG Wei1, ZHANG Yun1, ZHONG Ming1   

  1. 1. Department of Cardiology, Qilu Hospital of Shandong University, Key Laboratory of Cardiovascular Remodeling and
    Function Research,  Chinese Ministry of Education and Ministry of Public Health, Jinan 250012, China;
    2. Department of Healthcare, Weihai Municipal Hospital, Weihai 264200, Shandong, China;
    3. Department of Healthcare, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong, China
  • Received:2010-04-12 Online:2010-07-16 Published:2010-07-16

摘要:

目的    探讨TRB3基因+251A/G多态性与代谢综合征(MS)患者左房功能改变的相关性。方法    选择MS患者177例,正常对照组156例。采用酚/氯仿法提取全血DNA,PCR-RFLP法检验受试者TRB3基因第二外显子+251A/G的多态性位点。应用应变率成像技术测量左房各壁的应变率。结果   +251A/G位点AA、AG+GG基因型和等位基因的频率分布在正常对照组和MS组,两组间差异有统计学意义(P均<0.05);与正常对照组相比,MS组左房平均收缩期应变率峰值(mean SSR)、平均舒张早期应变率峰值(mean ESR)显著降低(P均<0.001),提示MS患者左房储存器和管道功能显著减低,左房平均舒张晚期应变率峰值(mean ASR)差异无统计学意义(P>0.05),MS患者左房助力泵功能无显著变化;与AA基因型相比,AG+GG基因型者左房mean SSR、mean ESR和mean ASR均明显降低(P均<0.05);多元线性回归分析显示mean ESR、mean ASR与TRB3基因+251A/G多态性G等位基因之间存在数量依存关系(P<0.05)。结论   TRB3基因+251A/G多态性G等位基因与MS患者左房功能受损相关,在MS患者左房功能损害中可能起重要作用。

关键词: 代谢综合征;TRB3基因多态性;左房功能

Abstract:

Objective    To investigate the association of TRB3 gene +251A/G polymorphism with the alterations of left atrial function in the patietns with metabolic syndrome (MS) . Methods    A total of 177 MS patients and 156 gender- and age-matched healthy subjects as controls were included. Genomic DNA was obtained from peripheral blood leukocytes using standard phenol-chloroform extraction procedures. TRB3 gene +251A/G polymorphism was determined for all participants by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Strain rate imaging was preformed to assess left atrial function. Results    The distributions of genotypic and allelic frequencies of TRB3 gene +251A/G polymorphism showed significant differences between MS group and controls (all P<0.05).Compared with controls, the decreases in mean SSR and ESR, reflecting impairment of LA reservoir and conduit function in patients with MS, were significant (both P<0.001). However, mean ASR, an indicator of LA booster function, was similar in two groups (P>0.05). This finding suggested there were no changes in the booster function of left atrium. The carriers of G allele (AG and GG genotypes) demonstrated significantly lower mean SSR, mean ESR and mean ASR of left atrium than those in carriers of AA genotype in MS group (both P<0.05). Multiple linear regression analysis showed that G allele of TRB3 gene +251A/G polymorphism significantly correlated with mean ESR and mean ASR of LA (both P<0.05). Conclusion    TBB3 gene +251A/G polymorphism has been associated with alterations of LA function. The G allele of +251A/G polymorphism could be an important risk factor for deteriorations of LA function in the patients with metabolic syndrome.

Key words: Metabolic syndrome; TRB3 genetic polymorphisms; Left atrial function

中图分类号: 

  • R541.8
[1] 韩露1,王彬2,牟晓梅2,巩会平3,闫会敏1,王志浩1,张运1,张薇1,钟明1. 代谢综合征患者心脏损害与脂肪因子变化的临床研究[J]. 山东大学学报(医学版), 2011, 49(9): 63-.
[2] 于飞 李保应 石珊珊 王茜 张志勉 高海青. 中老年糖尿病患者无创心脏血流动力学的临床研究[J]. 山东大学学报(医学版), 2009, 47(12): 13-16.
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