您的位置:山东大学 -> 科技期刊社 -> 《山东大学学报(医学版)》

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (5): 93-96.

• 论文 • 上一篇    下一篇

儿童眼肌型重症肌无力的远期预后及相关因素

陈晶,孙若鹏,李保敏   

  1. 山东大学齐鲁医院儿童医疗中心,  济南 250012
  • 收稿日期:2009-12-07 出版日期:2010-05-16 发布日期:2010-05-16
  • 通讯作者: 李保敏(1967- ),女,博士,副教授,主要从事小儿神经系统疾病研究。 E-mail: lbmsqf@163.com
  • 作者简介:陈晶(1984- )女,硕士研究生,主要从事小儿神经系统疾病研究。

Long-term prognosis of ocular myasthenia gravis in children and its related factors

  1. Department of Pediatrics, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2009-12-07 Online:2010-05-16 Published:2010-05-16

摘要:

目的  探讨儿童眼肌型重症肌无力的远期预后及影响预后的相关因素。方法  选择88例发病年龄为2~14岁,初发为眼肌型重症肌无力的患儿为研究对象,随访5~10年,观察其远期预后,并采用Logistic回归模型分析其影响因素。结果  13例患者正规药物治疗2年后症状完全缓解,占14.77%;59例患者仍为眼肌型重症肌无力(包括26例症状缓解停药后复发者),占67.05%;16例患者转化为全身型重症肌无力,占18.18%,其中多数(9/16,56.25%)于发病后1年内转化为全身型重症肌无力。抗乙酰胆碱受体(AchR)抗体及胸腺异常(包括胸腺瘤和胸腺增生)与远期预后有显著相关性(P<0.05)。结论  儿童重症肌无力的预后有其自身特点,由眼肌型转化为全身型的发生率较成人低,抗AchR抗体阳性和胸腺异常是转化为全身型重症肌无力的重要危险因素。

关键词: 眼肌型重症肌无力;预后;抗AchR抗体;胸腺增生;胸腺瘤

Abstract:

Objective  To explore long-term prognosis of ocular myasthenia gravis(OMG) in children and its related factors. Method  s88 patients aged between 2 and 14 years at onset were selected for this follow-up survey, and they were primarily diagnosed as having OMG. The follow-up time was 5 years to 10 years. At the end of the follow-up, the long-term prognosis of OMG was evaluated and its related factors were analyzed by the Logistic regression. Results  At the end of the follow-up,13 patients (14.77%) were asymptomatic after taking drugs for about two years;59 patients (67.05%) remained having OMG throughout the follow-up duration, including 26 recrudescent patients after drug withdrawal;16 patients (18.18%) converted into generalized myasthenia gravis, most of whom (9/16, 56.25%) occurred within 1 year after onset. The long-term prognosis of OMG had a significant correlation with acetylcholine receptor (AchR) antibody and thymopathy, including thymoma and thymic hyperplasia(P<0.05). Conclusion  Prognosis of OMG in children has some distinctive characteristics and the probability of OMG converting into generalized myasthenia gravis is lower than that in adults. Several factors, such as AchR antibody and thymopathy, may have an impact on the risk of OMG developing into generalized disease in children.

Key words: Ocular myasthenia gravis; Prognosis; Acetylcholine receptor antibody; Thymic hyperplasia; Thymoma

中图分类号: 

  • R72
No related articles found!
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!