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山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (4): 94-97.

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慢性乙型肝炎患者不同肝功能状况与胃黏膜病变的相关性

李月荣1,2,韩增禄2,王磊1   

  1. 1. 山东大学医学院 山东大学第二医院感染/肝病科, 济南 250033;
    2. 章丘市人民医院感染性疾病科,山东 章丘 250200
  • 收稿日期:2009-11-23 出版日期:2010-04-16 发布日期:2010-04-16
  • 通讯作者: 王磊(1962- ),男,教授,主要从事病毒性肝炎研究。 Email:wlcrb@sdu.edu.cn
  • 作者简介:李月荣(1973- ),女,主治医师,主要从事病毒性肝炎临床研究。

Correlation between liver function state and stomach mucosal diseases in patients with chronic hepatitis B

LI Yuerong1,2, HAN Zenglu2, WANG Lei1   

  1. 1. The Second Hospital of Shandong University, Shandong University, Jinan 250033, China;
    2. The People′s Hospital of Zhangqiu, Zhangqiu 250200, Shandong, China
  • Received:2009-11-23 Online:2010-04-16 Published:2010-04-16

摘要:

目的  探讨慢性乙型肝炎患者不同肝功能状况与胃黏膜病变程度的相关性。方法  对30例首次发病的慢性乙型肝炎患者进行胃镜检查,同时取病理并与其肝功能指标、乙型肝炎病毒(HBV)DNA定量、凝血酶原时间(PT)进行了相关性分析。结果  慢性乙型肝炎患者胃黏膜病变表现多样,以慢行浅表性胃窦炎为主,病理显示主要为轻度及中度慢性炎症。单因素分析表明性别、年龄、血清HBV DNA在轻度及中度慢性胃炎组无明显差异(P>0.05),肝功能指标中白蛋白(ALB)、PT在两组中的差异具有统计学意义(P<0.05)。应用Logistic回归方程进行多因素分析表明,PT延长是慢性乙型肝炎患者胃黏膜病变程度的预测因子,P=0.049,OR=2.105(95%可信区间1.004~4.414)。结论  随肝功能损伤加重,胃黏膜病变程度加重,PT可作为胃黏膜病变程度的预测因素。

关键词: 乙型肝炎,慢性; 胃黏膜病变; 肝功能; 凝血酶原时间; 白蛋白

Abstract:

Objective  To investigate the correlation between different liver function states and the degree of stomach mucosal diseases in patients with chronic hepatitis B. Method  Thirty chronic hepatitis B patients with first onset, were examined by gastroscopy, and routine pathological examinations were performed.Liver function parameters,serum HBV DNA level and prothrombin time were tested and the correlation was analyzed. Results  The patients showed various stomach mucosal diseases and chronic superficial antral gastritis was predominate. Pathological examinations showed mild or intermediate chronic inflammation.Monovariate analysis indicated that sex, age, serum HBV DNA level had no significance between mild and intermediate chronic gastritis (P>0.05). Among the liver function parameters,albumin (ALB) and prothrombin time(PT)in mild chronic gastritis were significantly different from that in intermediate  chronic gastritis(P<0.05). Logistic regression indicated that prothrombin time prolongation can predict the degree of stomach mucosal disease in chronic hepatitis B patients, P=0.049, OR=2.105 (95%CI 1.0044.414). Conclusion  Degrees of stomach mucosal diseases become more severe as liver function is aggravated in chronic hepatitis B patients. Prothrombin time may be predictor for the degree of stomach mucosal disease.

Key words: Hepatitis B,chronic; Stomach mucosal disease; Liver function; Prothrombin time; Albumin

中图分类号: 

  • R512.6
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