关键词: 乙型肝炎，慢性； 胃黏膜病变； 肝功能； 凝血酶原时间； 白蛋白

Abstract:

Objective  To investigate the correlation between different liver function states and the degree of stomach mucosal diseases in patients with chronic hepatitis B． Method  Thirty chronic hepatitis B patients with first onset, were examined by gastroscopy, and routine pathological examinations were performed．Liver function parameters，serum HBV DNA level and prothrombin time were tested and the correlation was analyzed． Results  The patients showed various stomach mucosal diseases and chronic superficial antral gastritis was predominate． Pathological examinations showed mild or intermediate chronic inflammation．Monovariate analysis indicated that sex， age， serum HBV DNA level had no significance between mild and intermediate chronic gastritis (P＞0.05)． Among the liver function parameters，albumin (ALB) and prothrombin time（PT）in mild chronic gastritis were significantly different from that in intermediate  chronic gastritis(P＜0.05)． Logistic regression indicated that prothrombin time prolongation can predict the degree of stomach mucosal disease in chronic hepatitis B patients， P=0.049， OR=2.105 (95%CI 1.0044.414)． Conclusion  Degrees of stomach mucosal diseases become more severe as liver function is aggravated in chronic hepatitis B patients． Prothrombin time may be predictor for the degree of stomach mucosal disease．

Key words: Hepatitis B，chronic； Stomach mucosal disease； Liver function； Prothrombin time； Albumin