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山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (4): 98-.

• 论文 • 上一篇    下一篇

PCI对女性冠心病的临床价值及术前服用β-受体阻滞剂的作用

辛辉1,2,巩会平3,张蕊2,康维强4,葛志明1,张运1   

  1. 1. 山东大学齐鲁医院心内科, 济南 250012;  2. 青岛大学医学院附属医院心内科, 山东 青岛 266003;
    3. 青岛大学医学院附属医院特需保健科, 山东 青岛 266003;
    4. 青岛市市立医院老年病房, 山东 青岛 266003
  • 收稿日期:2009-12-25 出版日期:2010-04-16 发布日期:2010-04-16
  • 通讯作者: 葛志明(1955- ),男,教授,主要从事心律失常的基础和临床研究。 Email: gezhiming@medmail.com.cn
  • 作者简介:辛辉(1967- ),女,副教授,主要从事冠心病的诊断和治疗。 Email: xhqy2002@yahoo.com.cn
  • 基金资助:

    山东省卫生厅青年基金立项课题[2001(厅青基)6]。

Clinical evaluation of percutaneous coronary intervention and influence of β-adrenergic blocker on female patients with coronary heart disease

XIN Hui1,2, GONG Huiping3, ZHANG Rui2, KANG Weiqiang4, GE Zhiming1, ZHANG Yun1   

  1. 1. Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China;
    2. Department of Cardiology, Affiliated Hospital of Medical College, Qingdao    University, Qingdao 266003, Shandong, China;
    3. Department of Healthcare, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong, China;
    4. Department of Geriatrics, Qingdao Municipal Hospital, Qingdao 266003, Shandong, China
  • Received:2009-12-25 Online:2010-04-16 Published:2010-04-16

摘要:

目的  探讨女性冠心病经皮冠状动脉介入治疗(PCI)的临床特点及PCI治疗前服用β-受体阻滞剂对患者的保护作用。方法  选择冠心病患者,男191例作为男性组,女75例作为女性组,均于PCI治疗前服用β-受体阻滞剂,同时收集拟行PCI的女性患者50例,术前及术后均未服用β-受体阻滞剂。所有患者均行PCI,并抽取肘静脉血测定肾上腺素(E)、去甲肾上腺素(NE)、肌酸磷酸激酶同工酶(CK-MB)及肌钙蛋白T(TNT)。结果  与男性组比较,女性组的多支病变明显增高(P均<0.05),PCI术后出血事件、肾功能衰竭及死亡率等并发症均显著增加(P均<0.05)。与服用β受体阻滞剂女性组比较,未服用药物的患者PCI术前和术后E(P<0.01)、NE(P<0.05)均明显增高,术后CK-MB和TNT均显著增高(P均<0.01);其心血管事件(MACE)、心绞痛、心律失常、出血事件的发生率和死亡率均显著升高。结论  女性患者冠心病病情及PCI术后较男性严重,提前服用β-受体阻滞剂具有保护作用。

关键词: 冠状动脉硬化;女(雌)性;β受体阻滞剂;经皮冠状动脉介入治疗

Abstract:

Objective  To evaluate the clinical characteristics in female patients with coronary heart disease after percutaneous coronary intervention (PCI) and the protective influence of β-adrenergic blocker therapy on patients before PCI. Methods  We recruited 266 consecutive subjects with coronary heart disease (191 males, 75 females) treated withβ-adrenergic blocker before and after PCI. 50 consecutive subjects with coronary heart disease were also involved, but  they did not received βadrenergic blocker therapy. Data were examined for gender-specific differences regarding patients' characteristics, angiographic findings, procedural details and adverse events at 1 year after PCI. Also, a blood sample was collected from each subject to determine the levels of creatine kinase-MB, TNT, E and NE. Results   Compared with  male subjects, multi-vessel lesions were significantly higher in  female subjects. Also, women had significantly higher prevalence of cumulative vascular complications, renal failure and unadjusted mortality. E, NE, CKMB and TNT levels significantly increased before and after PCI in the female coronary heart disease subjects withoutβadrenergic blocker therapy compared with those treated with β-adrenergic blocker. Overall, female subjects withoutβadrenergic blocker therapy were more likely to have in-hospital major adverse cardiac events(MACE), recurrent angina, cardiac arrhythmias and vascular complications. Conclusion  Women who undergo PCI therapy for coronary heart disease often have severer coronary artery lesions and higher post-PCI complication and mortality rates. Oral administration of β-adrenergic blocker has a protective effect on female patients before PCI.

Key words: Coronary arteriosclerosis;Female; β  adrenergic blocker;  Percutaneous coronary intervention

中图分类号: 

  • R541.4
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