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山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (8): 97-99.

• 论文 • 上一篇    下一篇

脉搏波传导速度与脑血管病的相关性

来超,刘莉,谢兆宏,王存福,朱正禹,毕建忠   

  1. 山东大学第二医院神经内科, 济南 250033
  • 收稿日期:2009-02-10 发布日期:2009-08-16
  • 作者简介:来超(1972- ),男,主治医师,硕士研究生,主要从事脑动脉粥样硬化的研究。 Email:laichao@tom.com
  • 基金资助:

    山东省教育厅科技计划资助项目(J07WZ33)。

Pulse wave velocity and cerebrovascular diseases

LAI Chao, LIU Li, XIE Zhaohong, WANG Cunfu, ZHU Zhengyu, BI Jianzhong   

  1. Department of Neurology,Second Hospital of Shandong University, Jinan 250033, China
  • Received:2009-02-10 Published:2009-08-16

摘要:

目的探讨脉搏波传导速度(PWV)与脑血管病的相关性及其在脑血管病防治中的意义。方法测定89例急性脑血管病患者的颈动脉-股动脉脉搏波传导速度(cfPWV),30例非脑血管病查体者为对照,比较分析各组的cfPWV及脑血管病不同发病形式、发病部位患者的cfPWV,分析吸烟及饮酒对脑血管病患者血管改变的影响。结果① 脑梗死组和脑出血组的双侧cfPWV均明显高于对照组(P<0.01,P<0.05);② 皮质皮质下梗死组双侧cfPWV均明显高于小脑脑干组(P<0.01),皮质下梗死组分别与小脑脑干组及皮质皮质下梗死组的cfPWV差异不显著(P>0.05);③脑出血组按出血部位不同分组的cfPWV差异不显著(P>0.05);④ 脑血管病患者中,吸烟组双侧cfPWV均明显低于不吸烟组(P<0.05);不饮酒组、轻度饮酒组和大量饮酒组的cfPWV差异不明显(P>0.05)。结论① PWV是与脑梗死、脑出血的发生密切相关的重要因素;② 吸烟可能使发生脑血管病的PWV阈值下降,从而增加脑血管病的发生风险。

关键词: 脑梗死;脑出血;脉搏波传导速度

Abstract:

To investigate the association between pulse wave velocity(cfPWV) and cerebrovascular diseases and to promote the application of PWV in epidemiological studies of cerebrovascular diseases. Methods58 patients with acute cerebral infarction(CI) and 31 patients with acute intracerebral hemorrhage(ICH) were enrolled in this study.  Another 30 persons without cerebrovascular disease(CVD) served as the control group. Carotidfemoral pulse wave velocity(cfPWV) was determined and the clinical data such as age, sex, smoking, alcohol intake, location in CI patients and site of hemorrhage were analyzed. ResultCfPWV in patients with CI and ICH was significantly higher than that in the control group(P<0.01 and P<0.05). CfPWV in patients with infarction in the cortex and subcortex was higher than that in patients with infarction in the brain stem or cerebellum(P<0.01), there were no significant differences among patients with different hemorrhage location(P>0.05). Patients with CVD had a low cfPWV if they smoked(P<0.01). But there were no significant differences in patients with different levels of alcohol intake(P>0.05). ConclusionPWV may be an important risk factor relating to CI and ICH. Smoking may cause a decrease of thresholds of PWV and increases the risks of CVD.

Key words: Brain infarction; Cerebral hemorrhage; Pulse wave velocity

中图分类号: 

  • R743.3
毕建忠(1961- ),男,教授,博士生导师,主任医师,主要从事痴呆及脑血管病的研究。 Email:bjz@sdu.edu.cn
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