姜黄素对糖尿病大鼠肾脏结构和功能的影响

山东大学学报(医学版)

姜黄素对糖尿病大鼠肾脏结构和功能的影响

于冬青¹，刘金波²，邓华聪³

（1. 山东大学附属省立医院重症监护室, 济南 250021； 2. 山东大学齐鲁医院内分泌科, 济南 250012；
3. 重庆医科大学附属第一医院内分泌科, 重庆 400016)

收稿日期:1900-01-01 修回日期:1900-01-01 发布日期:2009-04-16

Influence of curcumin on structure and function of kidney in diabetic rats

YU Dongqing¹, LIU Jinbo²，　DENG Huacong³

(1. Intensive Care Unit, Shandong Provincial Hospital, Shandong University, Jinan 250021, China;
2. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China;
3. Department of Endocrinology, First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400016, China)

Received:1900-01-01 Revised:1900-01-01 Published:2009-04-16

摘要/Abstract

摘要： 目的观察姜黄素对糖尿病大鼠肾脏结构和功能的影响。方法用链脲佐菌素（STZ）诱导制备糖尿病大鼠模型，并随机分为糖尿病组和姜黄素治疗组，另设一正常对照组。治疗组给予姜黄素200?mg/(kg·d)灌胃,为期8周。然后进行肾脏形态学观察和血尿素氮（BUN）、血肌酐（Scr）、内生肌酐清除率(Ccr)、尿白蛋白排泄率(UAER)等的检测。结果糖尿病组大鼠Ccr、UAER、尿白蛋白/肌酐、肾小球平均截面积(MGA)、肾小球平均体积(MGV)均显著高于正常对照组（P＜0.01或P＜0.05）。光镜和电镜下观察显示，糖尿病组大鼠较正常对照组大鼠肾小球明显增大，细胞数目增多，基底膜节段性增厚，部分足细胞足突融合。姜黄素治疗组上述异常均明显减轻。三组大鼠间血BUN和 Scr两两比较无明显差异(P＞0.05)。结论姜黄素可明显改善糖尿病大鼠肾脏病理改变，减轻肾脏肥大和高滤过状态，降低尿白蛋白，对糖尿病大鼠有肾脏保护作用。

关键词: 姜黄素, 糖尿病, 大鼠,Wistar, 肾脏

Abstract: To explore the effect of curcumin on the structure and function of the kidney in diabetic rats. MethodsDiabetes was induced by a single intraperitoneal injection of streptozoticin(STZ) to male Wistar rats at a dose of 60?mg/kg body weight and they were randomly divided into two groups: the diabetes group (group D) and the diabetes treated with curcumin group(group DC). A normal control group (group N) was also designed. Curcumin was given at a dose of 200?mg·kg-1·day-1, the other two groups were given the same quantity of CarboxylmethylCellulose(CMC). After a treatment of 8 weeks, renal morphology and blood and urinary biochemistry were evaluated. ResultsLevels of clearance of creatinine(Ccr)， urinary albumin excretion rate(UAER), albumincreatinine ratio(Alb/Cr), mean glomerular area(MGA) and mean glomerular volume(MGV) were all significantly increased in group D as compared with group N(P＜0.01 or P＜0.05) . Large glomeruli，membranes with a thickened glomerular basement, and foot processes confluence into podocytes were found by light microscopy and electron microscopy. All these abnormalities were markedly ameliorated after a curcumin treatment. ConclusionCurcumin is effective in improving renal pathological damage, ameriorating hypertrophy and hyperfiltration, and decreasing the urinary albumin excretion rate(UAER)in diabetic Wistar rats.

Key words: Curcumin, Diabetic mellitus, Wistar rats, Kidney

中图分类号:

R282.71

于冬青1 ，刘金波2 ，邓华聪3
. 姜黄素对糖尿病大鼠肾脏结构和功能的影响[J]. 山东大学学报(医学版), 2009, 47(04): 42-45.

YU Dongqing¹, LIU Jinbo²，　DENG Huacong³
.

Influence of curcumin on structure and function of kidney in diabetic rats

[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(04): 42-45.

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