关键词: 宫颈肿瘤, 淋巴转移, 淋巴管生成, 淋巴管内皮透明质酸受体

Abstract: To investigate the expression and its clinical significance of lymphatic vessels density (LVD) stained by lymphatic vessel endothelial hyaluronan receptor1（LYVE1）in the earlystage of invasive carcinoma of cervical uteri. MethodsImmunohistochemical staining with LYVE1 was used to determine LVD in 41 cases of earlystage of invasive carcinoma of cervical uteri and 12 cases of normal cervical uteri, and their correlation with tumor clinicopathological features was analyzed. Results①The majority of peritumoral lymphatic vessels was often enlarged and irregular. In contrast, the intratumoral lymphatic vessels were small and collapsed. The peritumoral lymphatic vessels density (PLVD) was significantly higher than the intratumoral lymphatic vessels density (ILVD)(P＜0.01). Compared with the LVD of benign cervix, both ILVD and PLVD were more significantly increased (P＜0.01).②Both ILVD and PLVD in patients with lymph nodal metastasis were significantly higher than those without lymph nodal metastasis (P＜0.05, P＜0.01). The same happened in the relationship between lymphatic vessel invasion and ILVD or PLVD (P＜0.05, P＜0.01). Both ILVD and PLVD in patients with histological grade G2 and G3 were more significantly increased than G1 (P＜0.05), but there were no differences between G2 and G3 (P＞0.05). ConclusionCompared with the LVD of benign cervix, both ILVD and PLVD are significantly increased and correlated with lymph node metastasis and lymphatic vessel invasion. Tumor lymphangiogenesis in the earlystage of invasive carcinoma of cervical uteri may play an important role in the process of lymphatic metastasis.