Graves病复发患者外周血中转化生长因子β1水平的变化

山东大学学报(医学版) ›› 2209, Vol. 47 ›› Issue (6): 80-.

Graves病复发患者外周血中转化生长因子β1水平的变化

张莹王宏伟王慧陈福琴

山东大学齐鲁医院内分泌科，济南 250012

收稿日期:2008-12-04 出版日期:2009-06-16 发布日期:2209-06-25
通讯作者: 陈福琴，女,教授,研究方向为内分泌疾病。 E-mail:chenfuqin@medmail.com.cn
作者简介:张莹(1981- ),女,硕士研究生,研究方向为甲状腺疾病。 E-mail：zhangxinxin0524@163.com

Changes of serum transforming growth factor-β1 level in patients with recurrence of Graves′ disease

ZHANG Ying, WANG Hong-Wei, WANG Hui, CHEN Fu-Qin

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China

Received:2008-12-04 Online:2009-06-16 Published:2209-06-25

摘要/Abstract

摘要：

目的探讨血清中转化生长因子β1（TGF-β1）在Graves病复发中的作用。方法收集在本院门诊就诊的Graves病患者60例，分为Graves病初诊组20例，Graves病治疗3个月组20例，Graves病复发组20例，健康对照组20例来自本院健康查体人群。应用ELISA方法测定各组血清TGF-β1及促甲状腺激素受体抗体（TRAb）的水平，采用电化学发光方法测定各组血清甲状腺激素水平及甲状腺过氧化酶抗体(TPOAb)、甲状腺球蛋白抗体（TGAb）的水平。结果 Graves病初诊组和复发组血清TGF-β1水平均较健康对照组显著增高（P<0.01），治疗3个月组血清TGF-β1水平较初诊组显著降低（P<0.01），复发组血清TGF-β1水平低于初诊组（P<0.01），但明显高于治疗3个月组（P<0.01）。结论血清TGF-β1可能参与了Graves病的发生及复发过程。

关键词: 格雷夫斯病；转化生长因子β1；复发

Abstract:

Objective To explore the role of serum transforming growth factor-β1(TGF-β1) in the recurrence of Graves disease. Methods 60 cases of Graves disease were divided into 3 groups: the new diagnosis group, the 3-month treatment group, and the recurrence group. 20 healthy persons served as the control group. Serum TGF-β1 and TRAb levels were determined by ELISA, and levels of serum thyroid hormone, TPOAb and TGAb were determined by electrochemiluminescence. Results The TGF-β1 level of the new diagnosis and recurrent groups was significantly higher than that of the control group（P<0.01）, of the 3-month treatment group was significantly lower compared with the new diagnosis group（P<0.01）, and of the recurrent group was lower than that of the new diagnosis group but higher than that of the 3-month treatment group（P<0.01）. Conclusion Serum TGF-β1 may be involved in the occurrence of Graves disease and its recurrence.

Key words: Graves′ disease; Transforming growth factor

中图分类号:

R581.1

张莹王宏伟王慧陈福琴. Graves病复发患者外周血中转化生长因子β1水平的变化[J]. 山东大学学报(医学版), 2209, 47(6): 80-.

ZHANG Ying, WANG Hong-Wei, WANG Hui, CHEN Fu-Qin. Changes of serum transforming growth factor-β1 level in patients with recurrence of Graves′ disease[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 80-.

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