聚乙丙交酯膜预防硬膜外瘢痕粘连的实验研究

山东大学学报(医学版) ›› 2209, Vol. 47 ›› Issue (6): 33-.

聚乙丙交酯膜预防硬膜外瘢痕粘连的实验研究

李彦明李冬青陈鹏张科峰

1. 山东大学齐鲁医院骨创科； 2. 山东大学第二医院手术室； 3. 山东大学第二医院骨外二科，济南 250033

收稿日期:2208-07-04 出版日期:2009-06-16 发布日期:2209-06-25
通讯作者: 陈鹏(1976- )，男，主治医师，硕士研究生，主要从事脊柱研究。 E-mail:chenpeng121@126.com
作者简介:李彦明(1981- )，男，硕士研究生，主要从事脊柱研究。E-mail: lym20050404@yahoo.com
基金资助:
济南市科技攻关资助项目（编号066029）。

PLGA membrane in prevention of epidural scar adhesions after the operations: an empirical study

LI Yan-Meng, LI Dong-Qing, CHEN Peng, ZHANG Ke-Feng

1. Department of Orthopaedics Trauma, Qilu Hospital of Shandong University; 2. Operating Room, Second Hospital of Shandong University; 3. Second Department of Orthopaedics, Second Hospital of Shandong University, Jinan 250033, China

Received:2208-07-04 Online:2009-06-16 Published:2209-06-25

摘要/Abstract

摘要：

目的观察新型生物可吸收材料聚乙丙交酯（poly lactate glycollic acid, PLGA）薄膜预防椎板切除术后硬膜外瘢痕粘连的作用，并与临床常用的明胶海绵进行比较。方法 36只成年新西兰雄兔切除L6（第6腰椎）椎板，制作椎板切除模型，在椎板缺损处分别覆盖PLGA膜（A组）、明胶海绵（B组）、0.9%生理盐水（C组）。术后每日观察动物的一般情况，第2、4、8周每组各处死四只，取标本行大体、组织学观察，术后2、4周同时行超微结构观察。结果与对照组相比，PLGA膜可以明显减轻术后硬脊膜与硬膜外瘢痕之间的粘连；明胶海绵不能减轻硬膜外瘢痕粘连。结论 PLGA膜能有效减轻硬脊膜与硬膜外瘢痕之间的粘连而不影响刀口的愈合，临床应用前景广阔。

关键词: 聚乙丙交酯膜;椎板切除术;硬膜外粘连;预防

Abstract:

Objective To explore the prophylactic function of a newly produced, absorbable PLGA membrane in the prevention ofepidural scar adhesions after laminectomy. Methods 36 adult New Zealand male rabbits which had under gone resection of the L6 vertebral plates were divided them into 3 groups: the defects of vertebral plate were covered with PLGA membrane (group A), gelatin sponge (group B) and saline solution (group C). Morphological changes of the scar were grossly and histologically observed on week 2, 4 and 8 after the operations, and also the ultra-structures were observed. Results Compared with the blank group, the PLGA membrane obviously reduced epidural adhesions; at an early stage, the gelatin sponge formed a physicobarrier, which lessened the epidural scar formation, as well as the PLGA membrane, but it latter made the adhesions even worse. Conclusion The PLGA membrane can lessen epidural scar adhesions without interfering in cutting edge healing.

Key words: Poly lactate geycollic acid membrane; Laminectomy; Epidural adhesions; Prevention

中图分类号:

R687.3

李彦明李冬青陈鹏张科峰. 聚乙丙交酯膜预防硬膜外瘢痕粘连的实验研究[J]. 山东大学学报(医学版), 2209, 47(6): 33-.

LI Yan-Meng, LI Dong-Qing, CHEN Peng, ZHANG Ke-Feng. PLGA membrane in prevention of epidural scar adhesions after the operations: an empirical study[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 33-.

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