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山东大学学报(医学版) ›› 2209, Vol. 47 ›› Issue (6): 124-.

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血清脂联素水平与肥胖、胰岛素抵抗的关系探讨

张媛 李英敏 冯月秋 常彩云 潘华伟 王束玫   

  1. 1. 山东大学公共卫生学院流行病与卫生统计学研究所, 济南 250012;2. 济南市历下区人民医院, 济南 250011
  • 收稿日期:2008-05-15 出版日期:2009-06-16 发布日期:2209-06-25
  • 通讯作者: 王束玫(1957- ),女,博士,教授,研究方向为慢性病流行病学。 E-mail:wshm@sdu.edu.cn
  • 作者简介:张媛(1982- ),女,硕士研究生,研究方向为慢性病流行病学。E-mail:zhangyuan-168@163.com

Relationship among serum adiponectin level, obesity and insulin resistance

 ZHANG Yuan, LI Yang-Min, FENG Rue-Qiu, CHANG Cai-Yun, PAN Hua-Wei, WANG Shu-Mei   

  1. 1. Department of Epidemiology and Health Statistics of School of Public Health, Shandong University, Jinan 250012, China;2. People′s Hospital of Lixia District of Jinan, Jinan 250011, China
  • Received:2008-05-15 Online:2009-06-16 Published:2209-06-25

摘要:

目的 探讨血清脂联素水平与胰岛素抵抗之间的关系,以及肥胖和胰岛素抵抗的交互作用对脂联素的影响。方法  将167例研究对象分成胰岛素抵抗伴肥胖、单纯胰岛素抵抗、单纯肥胖和正常状态四组,运用方差分析、协方差分析对观察指标进行研究。结果 在扣除性别、收缩压、舒张压、甘油三酯和高密度脂蛋白胆固醇对血清脂联素水平的线性影响后,脂联素在四组中的修正均数依次为3.477μg/mL、3.681μg/mL、4.447μg/mL和4.614μg/mL(P=0.033),胰岛素抵抗伴肥胖组的血清脂联素水平明显低于单纯肥胖组(P=0.036)和正常组(P=0.009),未发现胰岛素抵抗和肥胖的交互作用的存在。结论 血清脂联素水平降低与胰岛素抵抗之间互为因果,肥胖和胰岛素抵抗均与脂联素水平下降独立相关。

关键词: 血清脂联素;肥胖;胰岛素抵抗

Abstract:

Objective  To investigate the relationship between serum adiponectin and insulin resistance and to explore the effects of obesity and insulin resistance interaction on the adiponectin level.  Methods  176 subjects were divided into 4 groups: the insulin resistance with obesity, the insulin resistance, the obesity and the control groups. Variance and covariance analyses were used in this study.  Results   After ruling out the linear interference with adiponectin from gender, systolic blood pressure, diastolic blood pressure, triglycerides and high-density lipoprotein cholesterol, the modified means of serum adiponectin levels in the four groups were 3.477μg/mL, 3.681μg/mL, 4.447μg/mL and 4.614μg/mL(P=0.033), respectively. Adiponectin in the insulin resistance with obesity group was significantly lower than that in the obesity group (P=0.036) and the control group (P=0.009). Conclusions  The relationship between serum reduced adiponectin and insulin resistance may be bi-directional. Both obesity and insulin resistance are independently correlated with serum adiponectin.

Key words: serum adiponectin; obesity; insulin resistance

中图分类号: 

  • R781.6+3
[1] 张媛 李英敏 冯月秋 常彩云 潘华伟 王束玫. 血清脂联素水平与肥胖、胰岛素抵抗的关系探讨[J]. 山东大学学报(医学版), 2009, 47(6): 124-.
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