老年性痴呆患者尿中AD7c-NTP含量的研究

山东大学学报(医学版) ›› 2209, Vol. 47 ›› Issue (6): 106-.

老年性痴呆患者尿中AD7c-NTP含量的研究

闫鹏王蓉杜怡峰沈伦乾

1.山东大学附属省立医院神经内科，济南 250021； 2.首都医科大学宣武医院神经内科，北京脑老化研究实验室，北京 100053

收稿日期:2009-01-07 出版日期:2009-06-16 发布日期:2209-06-25
通讯作者: 杜怡峰（1962- ），男，博士后，教授，主要从事老年性痴呆、神经变性病以及脑血管病发病机制及防治研究。 E-mail:duyifengpmd2000@yahoo.com.cn
作者简介:闫鹏（1983- ），男，硕士研究生，主要从事老年性痴呆发病机制及防治的研究。E-mail：falconyp@126.com

AD7c-NTP level in urine of patients with Alzheimer′s disease

YAN Peng, WANG Rong, DU Yi-Feng, SHEN Lun-Qian

1. Department of Neurology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; 2. Beijing Brain Aging Research Institute, Xuan Wu Hospital, Capital University of Medical Sciences, Beijing 100053, China

Received:2009-01-07 Online:2009-06-16 Published:2209-06-25

摘要/Abstract

摘要：

目的探讨尿中阿尔茨海默病相关的神经丝蛋白（AD7c-NTP）含量在老年性痴呆（AD）诊断中的价值。方法采用酶联免疫吸附测定法（ELISA），检测AD组（分轻、中、重3组）65例、血管性痴呆组(VaD组) 60例、智能正常老年对照组120例尿液中AD7c-NTP含量，所有数据均经SPSS 13.0软件进行统计学处理。结果AD组、VaD组与智能正常老年对照组尿液中AD7c-NTP含量分别为(2.50±0.45)、(1.19±0.68) 、(1.21±0.74) ng/mL，AD组明显高于另外两组，而VaD组与智能正常老年对照组差异无统计学意义（P>0.05）； AD组内患者尿液AD7c-NTP含量与其痴呆程度呈正相关。结论尿液中AD7c-NTP含量在AD诊断和病情评估中有重要的临床参考价值。

关键词: 阿尔茨海默病；痴呆,血管性；阿尔茨海默病相关的神经丝蛋白；酶联免疫吸附测定；尿

Abstract:

Objective To explore the value of urine AD7c-NTP assay in clinical diagnosis of Alzheimer's disease (AD). Methods The urine AD7c-NTP level was determined using Enzyme-linked immunosorbent assay in 245 elderly people, who were divided into three groups: the AD group(n=65)，the vascular dementia group (VaD, n=60) and the normal mental state group (n=120). Statistical analysis was performed using SPSS 13.0. Results The urine AD7cNTP content of the three groups were (2.50±0.45)ng/ml, (1.19±0.68)ng/ml and (1.21±0.74)ng/ml. Compared with the normal mental state group and the VaD group, AD group had a significant increase of the urine AD7c-NTP level, which was positively correlated with the severity of the disease. No significant difference was found between the VaD group and the normal mental state group. Conclusion Urine AD7c-NTP level, probably a biochemical marker of AD, is of important and practical value in clinical diagnosis and condition assessment of AD.

Key words: Alzheimer disease; Dementia, vascular; AD7c-NTP; Enzymelinked immunosorbent assay; Urine

中图分类号:

R741.04

闫鹏王蓉杜怡峰沈伦乾. 老年性痴呆患者尿中AD7c-NTP含量的研究[J]. 山东大学学报(医学版), 2209, 47(6): 106-.

YAN Peng, WANG Rong, DU Yi-Feng, SHEN Lun-Qian. AD7c-NTP level in urine of patients with Alzheimer′s disease[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 106-.

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[1]	杨丽玲，王璐，任晓燕，韩晓娟，杜怡峰. JAK/STAT途径介导Aβ寡聚体诱导小胶质细胞TNF-α的释放[J]. 山东大学学报(医学版), 2010, 48(7): 33-36.
[2]	闫鹏王蓉杜怡峰沈伦乾. 老年性痴呆患者尿中AD7c-NTP含量的研究[J]. 山东大学学报(医学版), 2009, 47(6): 106-.