山东大学学报 (医学版) ›› 2026, Vol. 64 ›› Issue (1): 8-18.doi: 10.6040/j.issn.1671-7554.0.2025.0960
• 重点专题——精神与睡眠问题的机制证据与转化 • 上一篇 下一篇
陈婉毓,黄莉莉,卞宏生,王艳艳,于爽,金阳
CHEN Wanyu, HUANG Lili, BIAN Hongsheng, WANG Yanyan, YU Shuang, JIN Yang
摘要： 睡眠障碍与认知功能障碍是现代社会常见的共患病症,两者在病理机制存在密切关联。磷脂酰肌醇3-激酶/蛋白激酶B(phosphatidylinositol 3-kinase-protein kinase B, PI3K/AKT)信号通路在神经保护、代谢调节及突触可塑性中发挥核心作用,因此被视为干预此类疾病的重要靶点。近年研究发现,中药单体、提取物及其复方能够通过激活PI3K/AKT通路,改善睡眠与认知功能损害。本文在概述PI3K/AKT通路功能及其调控机制的基础上,系统归纳了中药单体、提取物及复方通过调节该信号通路改善睡眠障碍和认知障碍的研究进展,揭示其在共病治疗中的潜在作用,为基于传统医学开发神经精神疾病联合疗法及中药新药研发提供理论依据。
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